Phenol, 3-[[2-[(diethylamino)methyl]phenyl]thio]-

Base Information

• Chemical Name: Phenol, 3-[[2-[(diethylamino)methyl]phenyl]thio]-
• CAS No.: 127906-55-2
• Molecular Formula: C₁₇H₂₁NOS
• Molecular Weight: 287.426
• Mol file: 127906-55-2.mol

Synonyms:

Chemical Property of Phenol, 3-[[2-[(diethylamino)methyl]phenyl]thio]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 3-[[2-[(diethylamino)methyl]phenyl]thio]-

There total 8 articles about Phenol, 3-[[2-[(diethylamino)methyl]phenyl]thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

Diethyl-[2-(3-methoxy-phenylsulfanyl)-benzyl]-amine (127906-05-2) → 3-(2-Diethylaminomethyl-phenylsulfanyl)-phenol (127906-55-2)

Guidance literature:

With pyridine hydrochloride; at 210 - 220 ℃; for 0.5h;

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → 3-(2-Diethylaminomethyl-phenylsulfanyl)-phenol (127906-55-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / K₂CO₃, Cu / dimethylformamide / 12 h / Heating

2: 95 percent / SOCl₂, DMF / benzene / 2 h / Heating

3: 95 percent / benzene / 1 h / Ambient temperature

4: 71 percent / LiAlH₄ / benzene; diethyl ether / 6 h / Heating

5: 56 percent / pyridine hydrochloride / 0.5 h / 210 - 220 °C

With lithium aluminium tetrahydride; thionyl chloride; pyridine hydrochloride; copper; potassium carbonate; N,N-dimethyl-formamide; In diethyl ether; N,N-dimethyl-formamide; benzene;

Reference yield:

2-Iodobenzoic acid (88-67-5) → 3-(2-Diethylaminomethyl-phenylsulfanyl)-phenol (127906-55-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / KOH, Cu / H₂O / 14 h / Heating

2: 95 percent / SOCl₂, DMF / benzene / 2 h / Heating

3: 95 percent / benzene / 1 h / Ambient temperature

4: 71 percent / LiAlH₄ / benzene; diethyl ether / 6 h / Heating

5: 56 percent / pyridine hydrochloride / 0.5 h / 210 - 220 °C

With potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; pyridine hydrochloride; copper; N,N-dimethyl-formamide; In diethyl ether; water; benzene;

upstream raw materials:

Diethyl-[2-(3-methoxy-phenylsulfanyl)-benzyl]-amine

3-methoxyphenyl bromide

2-Iodobenzoic acid

3-methoxybenzenethiol