Chemical Property of Concanamycin A, >=70% (HPLC)
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:179-180℃ (dichloromethane ethanol )
- Boiling Point:966.4°Cat760mmHg
- PKA:12.46±0.70(Predicted)
- Flash Point:538.3°C
- PSA：225.92000
- Density:1.2g/cm3
- LogP:5.68420
- Storage Temp.:−20°C
- Solubility.:Soluble in DMSO
- XLogP3:6
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:14
- Rotatable Bond Count:12
- Exact Mass:865.51875607
- Heavy Atom Count:61
- Complexity:1580
- Purity/Quality:
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≥ 98% *data from raw suppliers
Concanamycin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+
- Statements:
26/27/28-36
- Safety Statements:
26-36/37/39-45
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
- Isomeric SMILES:CCC1C(C(C/C(=C/C=C/C(C(OC(=O)/C(=C/C(=C/C(C1O)C)/C)/OC)C(C)C(C(C)[C@@]2(C[C@H]([C@@H](C(O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
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Description
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
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Uses
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins. Concanamycin A has been used: as a lysosomal inhibitor in young and old fibroblasts as a vacuolar-type H+-ATPase inhibitor in presynaptic vesiclesas a lysosomal acidification blocker in HepG2 hepatocytes cells
