3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one

Base Information

Chemical Name:3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one
CAS No.:128317-50-0
Molecular Formula:C₂₀H₁₈FN₃O₂S
Molecular Weight:383.446
Hs Code.:
Mol file:128317-50-0.mol

Synonyms:3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluoro-phenyl)-thiazolidin-4-one;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one

Chemical Property:

PSA：72.54000
LogP:3.46710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one

There total 4 articles about 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)-1,3-thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 128317-50-0
3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)thiazolidin-4-one

Guidance literature:: With sodium sulfate; In toluene; for 6h; Reflux;

In toluene; for 18h; Reflux;

Reference yield: 41.0%

: 68-11-1
mercaptoacetic acid

: 72425-87-7
4-(4-fluorobenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one

: 128317-50-0
3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)thiazolidin-4-one

Guidance literature:: In benzene; for 5h; Heating;
DOI:10.1016/0223-5234(90)90016-V

Reference yield:

: 83-07-8
4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

: 128317-50-0
3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenyl)thiazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / ethanol / 1 h / Heating

2: 41 percent / benzene / 5 h / Heating

In ethanol; benzene;
DOI:10.1016/0223-5234(90)90016-V