4-(4-Methylphenyl)sulfonylthiophene-2-sulfonamide

Base Information

Chemical Name:4-(4-Methylphenyl)sulfonylthiophene-2-sulfonamide
CAS No.:128348-32-3
Molecular Formula:C11H11NO4S3
Molecular Weight:317.411
Hs Code.:
ChEMBL ID:CHEMBL333588
DSSTox Substance ID:DTXSID30872212
Nikkaji Number:J513.639C
Mol file:128348-32-3.mol

Synonyms:128348-32-3;CHEMBL333588;DTXSID30872212;4-(4-Methylbenzene-1-sulfonyl)thiophene-2-sulfonamide

Suppliers and Price of 4-(4-Methylphenyl)sulfonylthiophene-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Methylphenyl)sulfonylthiophene-2-sulfonamide

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:316.98502135
Heavy Atom Count:19
Complexity:509

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C2=CSC(=C2)S(=O)(=O)N

Technology Process of 4-(4-Methylphenyl)sulfonylthiophene-2-sulfonamide

There total 3 articles about 4-(4-Methylphenyl)sulfonylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 119731-32-7
4-<(4-methylphenyl)sulfonyl>thiophene-2-sulfonyl chloride

: 128348-32-3
4-(4-Methylphenylsulfonyl)thiophene-2-sulfonamide

Guidance literature:: With ammonia; In chloroform; for 16h; Ambient temperature;
DOI:10.1002/jhet.5570270202

Reference yield:

: 62141-76-8
3-<(4-methylphenyl)sulfonyl>thiophene

: 128348-32-3
4-(4-Methylphenylsulfonyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

2: 80 percent / NH₃ (gas) / CHCl₃ / 16 h / Ambient temperature

With chlorosulfonic acid; phosphorus pentachloride; ammonia; In chloroform;
DOI:10.1021/jm00099a010

Reference yield:

: 42057-02-3
3-<(4-methylphenyl)thio>thiophene

: 128348-32-3
4-(4-Methylphenylsulfonyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 1.5 h / 0 - 10 °C

2: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

3: 80 percent / NH₃ (gas) / CHCl₃ / 16 h / Ambient temperature

With chlorosulfonic acid; phosphorus pentachloride; ammonia; 3-chloro-benzenecarboperoxoic acid; In chloroform;
DOI:10.1021/jm00099a010