4-(4-Hydroxyphenyl)sulfonylfuran-2-sulfonamide

Base Information

Chemical Name:4-(4-Hydroxyphenyl)sulfonylfuran-2-sulfonamide
CAS No.:128348-44-7
Molecular Formula:C10H9NO6S2
Molecular Weight:303.317
Hs Code.:
ChEMBL ID:CHEMBL333747
DSSTox Substance ID:DTXSID30872217
Nikkaji Number:J513.635K
Mol file:128348-44-7.mol

Synonyms:128348-44-7;CHEMBL333747;DTXSID30872217;4-(4-Hydroxybenzene-1-sulfonyl)furan-2-sulfonamide

Suppliers and Price of 4-(4-Hydroxyphenyl)sulfonylfuran-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Hydroxyphenyl)sulfonylfuran-2-sulfonamide

Chemical Property:

XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:302.98712935
Heavy Atom Count:19
Complexity:509

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1O)S(=O)(=O)C2=COC(=C2)S(=O)(=O)N

Technology Process of 4-(4-Hydroxyphenyl)sulfonylfuran-2-sulfonamide

There total 5 articles about 4-(4-Hydroxyphenyl)sulfonylfuran-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 128348-35-6
4-(4-Methoxyphenylsulfonyl)furan-2-sulfonamide

: 128348-44-7
4-(4-Hydroxyphenylsulfonyl)furan-2-sulfonamide

Guidance literature:: With boron tribromide; In dichloromethane; 1,2-dichloro-ethane; for 16h; Heating;
DOI:10.1002/jhet.5570270202

Reference yield:

: 5335-87-5
4,4'-dimethoxyphenyl disulfide

: 128348-44-7
4-(4-Hydroxyphenylsulfonyl)furan-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-butyllithium / 1.) ether, hexane, -78 deg C, 45 min, 2.) ether, hexane, from -78 deg C to RT, overnight

2: m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 1.5 h / 0 - 10 °C

3: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

4: NH₃ (gas) / CHCl₃ / 16 h / Ambient temperature

5: boron tribromide / 1,2-dichloro-ethane; CH₂Cl₂ / 16 h / Heating

With chlorosulfonic acid; n-butyllithium; phosphorus pentachloride; ammonia; boron tribromide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; 1,2-dichloro-ethane;
DOI:10.1021/jm00099a010

Reference yield:

: 111943-73-8
3-((4-methoxyphenyl)thio)furan

: 128348-44-7
4-(4-Hydroxyphenylsulfonyl)furan-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 1.5 h / 0 - 10 °C

2: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

3: NH₃ (gas) / CHCl₃ / 16 h / Ambient temperature

4: boron tribromide / 1,2-dichloro-ethane; CH₂Cl₂ / 16 h / Heating

With chlorosulfonic acid; phosphorus pentachloride; ammonia; boron tribromide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; 1,2-dichloro-ethane;
DOI:10.1021/jm00099a010