3-Oxoisoindoline-4-carbonitrile

Base Information

• Chemical Name: 3-Oxoisoindoline-4-carbonitrile
• CAS No.: 129221-89-2
• Molecular Formula: C9H6N2O
• Molecular Weight: 158.15700
• Hs Code.: 2933790090
• DSSTox Substance ID: DTXSID20563021
• Nikkaji Number: J302.842I
• Wikidata: Q82447362
• Mol file: 129221-89-2.mol

Synonyms:129221-89-2;3-Oxoisoindoline-4-carbonitrile;7-CYANO-2,3-DIHYDRO-1H-ISOINDOLE-1-ONE;1H-Isoindole-4-carbonitrile, 2,3-dihydro-3-oxo-;3-Oxo-2,3-dihydro-1H-isoindole-4-carbonitrile;3-OXO-1,2-DIHYDROISOINDOLE-4-CARBONITRILE;2,3-Dihydro-3-oxo-1H-isoindole-4-carbonitrile;SCHEMBL2497009;DTXSID20563021;AKOS006332038;AM86089;SB32661;CS-0444202;F18514;A888887

Chemical Property of 3-Oxoisoindoline-4-carbonitrile

Chemical Property:

• PSA: 52.89000
• LogP: 1.13048
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 158.048012819
• Heavy Atom Count: 12
• Complexity: 253

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dihydro-3-oxo-1H-isoindole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C(=CC=C2)C#N)C(=O)N1

Technology Process of 3-Oxoisoindoline-4-carbonitrile

There total 3 articles about 3-Oxoisoindoline-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

7-Cyano-2,3-dihydro-3-hydroxy-1H-isoindol-1-one (129221-85-8) → 7-cyano-2,3-dihydro-1H-isoindole-1-one (129221-89-2) + 2,3-dihydro-7-hydroxymethyl-3-imino-1H-isoindol-1-one (129221-90-5) + 3-amino-2,3-dihydro-7-hydroxymethyl-1H-isoindol-1-one (129221-91-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 19h; Ambient temperature;

DOI:10.1246/bcsj.63.1160

Reference yield:

2,3-dicyanobenzaldehyde (129221-76-7) → 7-cyano-2,3-dihydro-1H-isoindole-1-one (129221-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂O, triethylamine / acetonitrile / 0.5 h / 20 °C

2: 13 percent / NaBH₄ / methanol / 19 h / Ambient temperature

With sodium tetrahydroborate; water; triethylamine; In methanol; acetonitrile;

DOI:10.1246/bcsj.63.1160

Reference yield:

3-((2,2-dimethylhydrazono)methyl)phthalonitrile (92011-72-8) → 7-cyano-2,3-dihydro-1H-isoindole-1-one (129221-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / aq. 12 M HCl / acetonitrile / Ambient temperature

2: 100 percent / H₂O, triethylamine / acetonitrile / 0.5 h / 20 °C

3: 13 percent / NaBH₄ / methanol / 19 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; water; triethylamine; In methanol; acetonitrile;

DOI:10.1246/bcsj.63.1160

upstream raw materials:

7-Cyano-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

2,3-dicyanobenzaldehyde

3-((2,2-dimethylhydrazono)methyl)phthalonitrile

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