4-Amino-5-fluoro-2-hydroxybenzonitrile

Base Information

Chemical Name:4-Amino-5-fluoro-2-hydroxybenzonitrile
CAS No.:129911-04-2
Molecular Formula:C7H5FN2O
Molecular Weight:152.128
Hs Code.:
DSSTox Substance ID:DTXSID00562375
Wikidata:Q82446500

Synonyms:4-amino-5-fluoro-2-hydroxybenzonitrile;129911-04-2;Benzonitrile, 4-amino-5-fluoro-2-hydroxy-;3-amino-6-cyano-4-fluorophenol;SCHEMBL6722032;DTXSID00562375;ONNXKOXERYZINB-UHFFFAOYSA-N;AKOS034086688;AT25968;CS-0498385;EN300-748749;Z1262633468

Suppliers and Price of 4-Amino-5-fluoro-2-hydroxybenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-Amino-5-fluoro-2-hydroxybenzonitrile

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:152.03859095
Heavy Atom Count:11
Complexity:188

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)N)O)C#N

Technology Process of 4-Amino-5-fluoro-2-hydroxybenzonitrile

There total 2 articles about 4-Amino-5-fluoro-2-hydroxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.4%

: 594813-24-8
4-amino-2-benzyloxy-5-fluorobenzonitrile

: 129911-04-2
4-amino-5-fluoro-2-hydroxybenzonitrile

Guidance literature:: 4-amino-2-benzyloxy-5-fluorobenzonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With potassium iodide; In water; at 20 ℃; for 72h;

Reference yield:

: 112279-61-5
4-amino-2,5-difluoro-benzonitrile

: 129911-04-2
4-amino-5-fluoro-2-hydroxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4 A molecular sieve; potassium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

2.2: 72 h / 20 °C

With hydrogenchloride; 4 A molecular sieve; potassium carbonate; sodium nitrite; In water; N,N-dimethyl-formamide;