Tezacitabine anhydrous, (Z)-

Base Information

Chemical Name:Tezacitabine anhydrous, (Z)-
CAS No.:130306-01-3
Molecular Formula:C10H12FN3O4
Molecular Weight:
Hs Code.:
UNII:7B597L8UYO
Wikidata:Q27896212

Synonyms:Tezacitabine anhydrous, (Z)-;7B597L8UYO;UNII-7B597L8UYO;Cytidine, 2'-deoxy-2'-(fluoromethylene)-, (2'Z)-;130306-01-3;(Z)-tezacitabine;SCHEMBL19098;Q27896212;4-amino-1-[(2R,3Z,4S,5R)-3-(fluoromethylene)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

Suppliers and Price of Tezacitabine anhydrous, (Z)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tezacitabine anhydrous, (Z)-

Chemical Property:

XLogP3:-2.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:257.08118403
Heavy Atom Count:18
Complexity:448

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CN(C(=O)N=C1N)C2C(=CF)C(C(O2)CO)O
Isomeric SMILES:C1=CN(C(=O)N=C1N)[C@H]2/C(=C\F)/[C@@H]([C@H](O2)CO)O

Technology Process of Tezacitabine anhydrous, (Z)-

There total 4 articles about Tezacitabine anhydrous, (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 135789-89-8,135789-88-7
(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

: 130306-01-3,171233-40-2
(Z)-2'-deoxy-2'-(fluoromethylene)cytidine

Guidance literature:: With ammonia; cesium fluoride; In methanol;
DOI:10.1021/ja00019a061

Reference yield:

: 132619-20-6
(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

: 130306-01-3,171233-40-2
(Z)-2'-deoxy-2'-(fluoromethylene)cytidine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; cesium fluoride; Yield given. Multistep reaction; 1.) benzene, 2.) methanol;
DOI:10.1021/ja00019a061

Reference yield:

: 113648-22-9
4-ethoxy-1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl>-2(1H)-pyrimidinone

: 130306-01-3,171233-40-2
(Z)-2'-deoxy-2'-(fluoromethylene)cytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 8.5 percent / LiHMDS, ClP(O)(OEt)2

2: 1.) Bu₃SnH, AlBN, 2.) CsF, NH₃ / 1.) benzene, 2.) methanol

With 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; diethyl chlorophosphate; cesium fluoride; lithium hexamethyldisilazane;
DOI:10.1021/ja00019a061