L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, heptyl ester

Base Information

• Chemical Name: L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, heptyl ester
• CAS No.: 130380-43-7
• Molecular Formula: C24H38N2O6
• Molecular Weight: 450.576
• Mol file: 130380-43-7.mol

Synonyms:

Chemical Property of L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, heptyl ester

There total 2 articles about L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) + L-Phenylalanin-heptylester-hydro-p-toluolsulfonat (130380-37-9) → N-tert-Butyloxycarbonyl-L-seryl-L-phenylalanin-heptylester (130380-43-7)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; for 12h; Ambient temperature;

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N-tert-Butyloxycarbonyl-L-seryl-L-phenylalanin-heptylester (130380-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / p-TsOH*H₂O / benzene / Heating

2: 67 percent / Et₃N, 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CH₂Cl₂ / 12 h / Ambient temperature

With toluene-4-sulfonic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; benzene;

Reference yield: 94.0%

N-tert-Butyloxycarbonyl-L-seryl-L-phenylalanin-heptylester (130380-43-7) → L-Seryl-L-phenylalanin-heptylester-hydrochlorid (130380-59-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 2h; Ambient temperature;

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)serine

L-Phenylalanin-heptylester-hydro-p-toluolsulfonat

L-phenylalanine

Downstream raw materials:

(S)-2-((S)-2-tert-butoxycarbonylamino-3-hydroxypropionylamino)-3-phenylpropionic acid

L-Seryl-L-phenylalanin-heptylester-hydrochlorid

Refernces