1-Benzyl-4-hydrazinylphthalazine

Base Information

• Chemical Name: 1-Benzyl-4-hydrazinylphthalazine
• CAS No.: 130538-61-3
• Molecular Formula: C15H14N4
• Molecular Weight: 250.303
• DSSTox Substance ID: DTXSID20562670
• Nikkaji Number: J405.625F
• Wikidata: Q82446921
• Mol file: 130538-61-3.mol

Synonyms:130538-61-3;Phthalazine, 1-hydrazinyl-4-(phenylmethyl)-;1-Benzyl-4-hydrazinylphthalazine;DTXSID20562670

Chemical Property of 1-Benzyl-4-hydrazinylphthalazine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 250.121846464
• Heavy Atom Count: 19
• Complexity: 277

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC2=NN=C(C3=CC=CC=C32)NN

Technology Process of 1-Benzyl-4-hydrazinylphthalazine

There total 6 articles about 1-Benzyl-4-hydrazinylphthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-benzylphthalazine-1(2H)-thione (59908-32-6) → 1-(4-benzylphthalazin-1-yl)hydrazine (130538-61-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1248/BPB.B15-00656

Reference yield: 60.0%

1-benzyl-4-chlorophthalazine (40848-53-1) → 1-(4-benzylphthalazin-1-yl)hydrazine (130538-61-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

Reference yield:

phthalic anhydride (85-44-9) → 1-(4-benzylphthalazin-1-yl)hydrazine (130538-61-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium acetate / 180 °C

2: hydrazine hydrate / ethanol / Heating

3: tetraphosphorus decasulfide / toluene / 2 h / Reflux

4: hydrazine hydrate / ethanol / 3 h / Reflux

With tetraphosphorus decasulfide; hydrazine hydrate; sodium acetate; In ethanol; toluene;

DOI:10.1248/BPB.B15-00656

upstream raw materials:

1-benzyl-4-chlorophthalazine

4-benzylphthalazine-1(2H)-thione

4-benzyl-2H-phthalazin-1-one

phthalic anhydride

Downstream raw materials:

7-benzyl-3-methyl-4-oxo-1,2,4-triazino<3,4-a>phthalazine

6-benzyl-3-methyl-1,2,4-triazolo<3,4-a>phthalazine

6-Benzyl-1,2,4-triazolo<3,4-a>phthalazine

6-Benzyl-3-(3-bromophenylaminocarbonylmethylthio)-s-triazolo<3,4-a>-phthalazine