Methyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate

Base Information

• Chemical Name: Methyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate
• CAS No.: 130613-19-3
• Molecular Formula: C11H7Cl2NO3
• Molecular Weight: 272.08400
• Hs Code.: 2933499090
• Mol file: 130613-19-3.mol

Synonyms:5,7-dichloro-4-hydroxy-2-methoxycarbonylquinoline,methyl ester;METHYL 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE;5,7-dichloro-4-hydroxyquinoline-2-carboxylic acid,methyl ester;

Chemical Property of Methyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate

Chemical Property:

• PSA: 59.42000
• LogP: 3.03380
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 5,7-dichloro-4-hydroxyquinoline-2-carboxylate

Technology Process of Methyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate

There total 1 articles about Methyl5,7-dichloro-4-hydroxyquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5,7-dichloro-4-hydroxyquinoline-2-carboxylic acid,methyl ester (130613-19-3)

Guidance literature:

Reference yield: 80.0%

Tosyl isocyanate (4083-64-1) + 5,7-dichloro-4-hydroxyquinoline-2-carboxylic acid,methyl ester (130613-19-3) → 5,7-Dichloro-4-(toluene-4-sulfonylamino)-quinoline-2-carboxylic acid methyl ester (130613-21-7)

Guidance literature:

In acetonitrile; Heating;

DOI:10.1021/jm00174a005

Reference yield:

5,7-dichloro-4-hydroxyquinoline-2-carboxylic acid,methyl ester (130613-19-3) → 5,7-Dichloro-4-[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-quinoline-2-carboxylic acid methyl ester (130613-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetonitrile / Heating

2: NaH / dimethylformamide

With sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00174a005

Downstream raw materials:

5,7-Dichloro-4-(toluene-4-sulfonylamino)-quinoline-2-carboxylic acid methyl ester

4-carboxymethyloxy-5,7-dichloro-2-quinolinecarboxylic acid

MDL 100,748

5,7-Dichloro-4-[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-quinoline-2-carboxylic acid methyl ester

Refernces

• 1、 -. "Platelet adenosine diphosphate receptor antagonists". . . Retrieved 2008/06/13.