6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine

Base Information

Chemical Name:6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine
CAS No.:29078-50-0
Molecular Formula:C11H10 Cl N S
Molecular Weight:223.7218
Hs Code.:2934999090
NSC Number:172256,137529
UNII:OCM9L239UO
DSSTox Substance ID:DTXSID80183325
Nikkaji Number:J394.831E
Wikidata:Q83054081
Mol file:29078-50-0.mol

Synonyms:29078-50-0;6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine;OCM9L239UO;UNII-OCM9L239UO;NSC 172256;NSC172256;NSC-172256;6-Chloro-1,2,3,4-tetrahydro-(1)benzothieno(2,3-C)pyridine;[1]Benzothieno[2, 6-chloro-1,2,3,4-tetrahydro-;6-chloro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-c]pyridine;6-Chloro-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridine;NSC137529;SCHEMBL3143656;DTXSID80183325;QUYWGYYUNJPLCY-UHFFFAOYSA-N;NSC-137529;6-chloro-1,2,3,4-tetrahydrobenzothiopheno[2,3-c]pyridine;{[1]Benzothieno[2,3-c]pyridine,} 6-chloro-1,2,3,4-tetrahydro-;(1)BENZOTHIENO(2,3-C)PYRIDINE, 6-CHLORO-1,2,3,4-TETRAHYDRO-;6-CHLORO-1,2,3,4-TETRAHYDRO-(1)BENZOTHIENO(2,3-C)-PYRIDINE

Suppliers and Price of 6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine

Chemical Property:

Vapor Pressure:5.02E-06mmHg at 25°C
Boiling Point:381.6°Cat760mmHg
Flash Point:184.6°C
PSA：40.27000
Density:1.332g/cm³
LogP:3.52920
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:223.0222482
Heavy Atom Count:14
Complexity:223

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC2=C1C3=C(S2)C=CC(=C3)Cl

Technology Process of 6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine

There total 8 articles about 6-Chloro-1,2,3,4-tetrahydro(1)benzothieno(2,3-c)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 6-chloro-3,4-dihydrobenzo[4,5]thieno[2,3-c]pyridine-2(1H)-carboxylic acid ethyl ester

: 29078-50-0
6-chloro-1,2,3,4-tetrahydrobenzo[4,5]thieno[2,3-c]pyridine

Guidance literature:: With sodium hydroxide; In ethanol; water; at 0 ℃; Reflux;
DOI:10.1016/j.ejmech.2017.03.037

Reference yield: 72.5%

: 29078-50-0
6-chloro-1,2,3,4-tetrahydrobenzo[4,5]thieno[2,3-c]pyridine

Guidance literature:: With sodium hydroxide; In ethanol; water; at 0 ℃;

Reference yield:

: 106-54-7
p-Chlorothiophenol

: 29078-50-0
6-chloro-1,2,3,4-tetrahydrobenzo[4,5]thieno[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: polyphosphoric acid / toluene / 16 h / 100 °C / Inert atmosphere

3: ammonia / methanol / 72 h / 23 °C

4: diborane / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6: toluene-4-sulfonic acid / toluene / 2 h / 115 °C

7: sodium hydroxide / ethanol; water / 0 °C / Reflux

With ammonia; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; diborane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 6: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2017.03.037