4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-

Base Information

Chemical Name:4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-
CAS No.:131278-92-7
Molecular Formula:C20H21F2NO2
Molecular Weight:345.389
Hs Code.:
DSSTox Substance ID:DTXSID10439423
Wikidata:Q82255376

Synonyms:131278-92-7;4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-;SCHEMBL9021050;DTXSID10439423;ABBCDSFUQJILPM-UHFFFAOYSA-N;1-[2-bis(4-fluorophenyl)methoxyethyl]-4-piperidone

Suppliers and Price of 4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:345.15403524
Heavy Atom Count:25
Complexity:386

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1=O)CCOC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F

Technology Process of 4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-

There total 3 articles about 4-Piperidinone, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 131278-94-9
1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidinol

: 131278-92-7
1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃;
DOI:10.1248/cpb.41.882

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 131278-92-7
1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidone

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Na₂CO₃, NaI / various solvent(s) / 9 h / Heating

2: 91 percent / (COCl)2, Et₃N, dimethylsulfoxide (DMSO) / CH₂Cl₂ / -60 - 20 °C

With oxalyl dichloride; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; In dichloromethane;
DOI:10.1248/cpb.41.882

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 131278-92-7
1-<2-bis(4-fluorophenyl)methoxyethyl>-4-piperidone

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Na₂CO₃, NaI / various solvent(s) / 9 h / Heating

2: 91 percent / (COCl)2, Et₃N, dimethylsulfoxide (DMSO) / CH₂Cl₂ / -60 - 20 °C

With oxalyl dichloride; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; In dichloromethane;
DOI:10.1248/cpb.41.882