1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea

Base Information

Chemical Name:1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea
CAS No.:13142-49-9
Molecular Formula:C12H9Cl2N3O
Molecular Weight:282.129
Hs Code.:
European Community (EC) Number:668-505-4
ChEMBL ID:CHEMBL311070

Synonyms:1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea;MLS001211197;1-(3,4-dichlorophenyl)-3-pyridin-2-ylurea;13142-49-9;SMR000515062;1-(3,4-dichlorophenyl)-3-(2-pyridyl)urea;Oprea1_213206;Oprea1_428944;Oprea1_723479;CHEMBL311070;cid_786649;SCHEMBL8020408;BDBM69881;HMS2873I11;STK325554;AKOS000633198;1-(3,4-dichlorophenyl)-3-(2-pyridinyl)urea;1-(3,4-dichlorophenyl)-3-pyridin-2-yl-urea;BRD-K19866816-001-04-4;N-(3,4-DICHLOROPHENYL)-N'-(2-PYRIDINYL)CARBAMIMIDIC ACID

Suppliers and Price of 1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
1-(3,4-DICHLOROPHENYL)-3-(2-PYRIDYL)UREA AldrichCPR
50mg
$ 144.00

Total 1 raw suppliers

Chemical Property of 1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea

Chemical Property:

Boiling Point:335.2±37.0 °C(Predicted)
PSA：54.02000
Density:1.508±0.06 g/cm3(Predicted)
LogP:4.17840
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:281.0122673
Heavy Atom Count:18
Complexity:291

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3,4-DICHLOROPHENYL)-3-(2-PYRIDYL)UREA AldrichCPR ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)NC(=O)NC2=CC(=C(C=C2)Cl)Cl

Technology Process of 1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea

There total 7 articles about 1-(3,4-Dichloro-phenyl)-3-pyridin-2-yl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 109-04-6
2-bromo-pyridine

: 2327-02-8
3,4-dichlorophenylurea

: 13142-49-9
1-(3,4-dichlorophenyl)-3-(pyridin-2-yl)urea

Guidance literature:: With t-BuBrettPhos; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 95 ℃; for 12h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.1c03468

Reference yield: 36.0%

: 2-amino-1-(2-ethoxy-2-oxoethyl)-pyridin-1-ium bromide

: 95-76-1
m,p-dichloroaniline

: 13142-49-9
1-(3,4-dichlorophenyl)-3-(pyridin-2-yl)urea

Guidance literature:: With potassium phosphate; In N,N-dimethyl-formamide; at 100 ℃; for 20h;
DOI:10.1016/j.tetlet.2019.07.030

Reference yield:

: 504-29-0
2-aminopyridine

: 13142-49-9
1-(3,4-dichlorophenyl)-3-(pyridin-2-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

2: potassium phosphate / N,N-dimethyl-formamide / 20 h / 100 °C

With potassium phosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2019.07.030