7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin

Base Information

Chemical Name:7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin
CAS No.:99033-29-1
Molecular Formula:C26H23ClN2O6S
Molecular Weight:526.9886
Hs Code.:
Mol file:99033-29-1.mol

Synonyms:(S)-N-(4-Chloro-3-methoxy-1-oxo-1H-isochromen-7-yl)-3-phenyl-2-(toluene-4-sulfonylamino)-propionamide;7-[(N-tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin;

Suppliers and Price of 7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：123.09000
Density:1.44g/cm³
LogP:5.83640

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin

There total 3 articles about 7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 62252-26-0
JLK 6

: 90365-18-7,29739-88-6
N-(p-toluenesulfonyl)-L-phenylalanyl chloride

: 99033-29-1
7-<(N-tosylphenylalanyl)amino>-4-chloro-3-methoxyisocoumarin

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00084a018

Reference yield:

: 62252-25-9
4-chloro-3-methoxy-7-nitroisocoumarin

: 99033-29-1
7-<(N-tosylphenylalanyl)amino>-4-chloro-3-methoxyisocoumarin

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethyl acetate; methanol

2: 35 percent / Et₃N / CH₂Cl₂; tetrahydrofuran / 2 h / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00084a018

Reference yield:

: 13505-32-3
N-tosyl-(S)-phenylalanine

: 99033-29-1
7-<(N-tosylphenylalanyl)amino>-4-chloro-3-methoxyisocoumarin

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 0.67 h / Heating

2: 35 percent / Et₃N / CH₂Cl₂; tetrahydrofuran / 2 h / Ambient temperature

With thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00084a018