Carbamic acid, [1-(azidomethyl)-4-oxobutyl](phenylmethyl)-, phenylmethyl ester, (S)-

Base Information

Chemical Name:Carbamic acid, [1-(azidomethyl)-4-oxobutyl](phenylmethyl)-, phenylmethyl ester, (S)-
CAS No.:132256-84-9
Molecular Formula:C20H22N4O3
Molecular Weight:366.42
Hs Code.:

Synonyms:

Suppliers and Price of Carbamic acid, [1-(azidomethyl)-4-oxobutyl](phenylmethyl)-, phenylmethyl ester, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [1-(azidomethyl)-4-oxobutyl](phenylmethyl)-, phenylmethyl ester, (S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [1-(azidomethyl)-4-oxobutyl](phenylmethyl)-, phenylmethyl ester, (S)-

There total 8 articles about Carbamic acid, [1-(azidomethyl)-4-oxobutyl](phenylmethyl)-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 132316-99-5
(S)-4--5-azido-pentan-1-ol

: 132256-84-9
(S)-4--5-azido-pentanal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jo00006a002

Reference yield:

: 77539-18-5,73914-82-6
(S)-(+)-2-benzylamino glutaric acid

: 132256-84-9
(S)-4--5-azido-pentanal

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / NaHCO₃ / H₂O / 3 h / Ambient temperature

2: 70 percent / BH₃*THF / tetrahydrofuran / 18 h / Ambient temperature

3: 88 percent / pyridine, DMAP / CH₂Cl₂ / 18 h / Ambient temperature

4: 83 percent / triphenylphosphine, diethyl azodicarboxylate, diphenylphosphoryl azide / tetrahydrofuran / 48 h / Ambient temperature

5: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature

6: 1) DMSO, oxalyl chloride, 3) Et₃N / 1) CH₂Cl₂, -78 deg C, 30 min, 2) CH₂Cl₂, -78 deg C, 1 h, 3) CH₂Cl₂, -> r.t., 2 h

With pyridine; dmap; borane-THF; oxalyl dichloride; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00040a045

Reference yield:

: 132316-96-2
(S)-N-benzyl-N-(benzyloxycarbonyl)glutamic acid

: 132256-84-9
(S)-4--5-azido-pentanal

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / BH₃*THF / tetrahydrofuran / 18 h / Ambient temperature

2: 88 percent / pyridine, DMAP / CH₂Cl₂ / 18 h / Ambient temperature

3: 83 percent / triphenylphosphine, diethyl azodicarboxylate, diphenylphosphoryl azide / tetrahydrofuran / 48 h / Ambient temperature

4: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature

5: 1) DMSO, oxalyl chloride, 3) Et₃N / 1) CH₂Cl₂, -78 deg C, 30 min, 2) CH₂Cl₂, -78 deg C, 1 h, 3) CH₂Cl₂, -> r.t., 2 h

With pyridine; dmap; borane-THF; oxalyl dichloride; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00040a045