Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-, hydrochloride

Base Information

• Chemical Name: Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-, hydrochloride
• CAS No.: 13233-00-6
• Molecular Formula: C19H21NO3.ClH
• Molecular Weight: 347.842

Synonyms:3,4-Dihydro-6,7-dimethoxy-1-(p-methoxybenzyl)isoquinoline Hydrochloride;

Chemical Property of Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-, hydrochloride

Chemical Property:

• PSA: 40.05000
• LogP: 3.53790

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dihydro-6,7-dimethoxy-1-(p-methoxybenzyl)isoquinolineHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dihydro-6,7-dimethoxy-1-(p-methoxybenzyl)isoquinoline Hydrochloride is an intermediate in the synthesis of (-)-Higenamine (H325800).

Technology Process of Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-, hydrochloride

There total 1 articles about Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-(4-methoxy-phenyl)-acetamide (4078-65-3) → 6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline hydrochloride (13233-00-6)

Guidance literature:

With trichlorophosphate; In chloroform; at 80 ℃; for 33h; Heating / reflux;

Reference yield: 85.0%

6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline hydrochloride (13233-00-6) → 6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline (72527-29-8)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; water; at 0 ℃; for 1h; Product distribution / selectivity;

Reference yield: 52.0%

6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline hydrochloride (13233-00-6) + C11H12BrFO2 (1213240-94-8) → 2-(5-fluoro-2-isopropoxyphenyl)-8,9-dimethoxy-1-(4-methoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline (1213240-85-7)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; for 8h; Reflux;

DOI:10.1016/j.ejmech.2009.09.017

upstream raw materials:

N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-(4-methoxy-phenyl)-acetamide

Downstream raw materials:

6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline

2-(5-fluoro-2-isopropoxyphenyl)-8,9-dimethoxy-1-(4-methoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline

4-(8,9-dimethoxy-1-(4-methoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)phenol

5-(8,9-dimethoxy-1-(4-methoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-2-methoxyphenol

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