methyl 3-(bromomethyl)-2-nitrobenzoate

Base Information

• Chemical Name: methyl 3-(bromomethyl)-2-nitrobenzoate
• CAS No.: 132874-06-7
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.071
• Mol file: 132874-06-7.mol

Synonyms:3-Bromomethyl-2-nitrobenzoic acid methyl ester;Methyl 3-(bromomethyl)-2-nitrobenzoate;

Chemical Property of methyl 3-(bromomethyl)-2-nitrobenzoate

Chemical Property:

• Boiling Point: 349.785 °C at 760 mmHg
• Flash Point: 165.345 °C
• Density: 1.625 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(bromomethyl)-2-nitrobenzoate

There total 4 articles about methyl 3-(bromomethyl)-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.2%

methyl 3-methyl-2-nitrobenzoate (5471-82-9) → methyl 3-(bromomethyl)-2-nitrobenzoate (132874-06-7)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 15 - 80 ℃; for 48h;

Reference yield:

2,2'-azobis(2-methylpropionitrile) (AIBN) + methyl 3-methyl-2-nitrobenzoate (5471-82-9) → methyl 3-(bromomethyl)-2-nitrobenzoate (132874-06-7)

Guidance literature:

In tetrachloromethane;

Reference yield:

3-methyl-2-nitrobenzoic acid (5437-38-7) → methyl 3-(bromomethyl)-2-nitrobenzoate (132874-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / H₂SO₄ / 24 h / Heating

2: 49 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

With N-Bromosuccinimide; sulfuric acid; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1016/j.tet.2004.01.026

upstream raw materials:

methyl 3-methyl-2-nitrobenzoate

3-methyl-2-nitrobenzoic acid

Downstream raw materials:

methyl 3-(methoxymethyl)-2-nitrobenzoate

(3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride

2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester

tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate

Refernces

• 1、 -. "Polyheterocyclic substituted pyrimidines or pyridylamine derivatives Composition and medical application thereof". Paragraph 0303-0305. . Retrieved 2021/09/26.
• 2、 -. "Derivative based on PARP inhibitor Niraparib and a preparation method and use thereof". Paragraph 0029; 0037-0043. . Retrieved 2019/10/29.