1-Piperidinecarboxylic acid, 4-methylphenyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-methylphenyl ester
• CAS No.: 132906-02-6
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 132906-02-6.mol

Synonyms:

Chemical Property of 1-Piperidinecarboxylic acid, 4-methylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-methylphenyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.3%

piperidine (110-89-4) + Carbonic acid chloromethyl ester p-tolyl ester (132905-79-4) → piperidine-1-carboxylic acid p-tolyl ester (132906-02-6)

Guidance literature:

In benzene; a.) RT, 1 h, b.) reflux, 1 h;

Reference yield:

p-cresol (106-44-5) → piperidine-1-carboxylic acid p-tolyl ester (132906-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79.3 percent / Et₃N / CH₂Cl₂ / 1.67 h / 5 °C

2: 55.3 percent / benzene / a.) RT, 1 h, b.) reflux, 1 h

With triethylamine; In dichloromethane; benzene;

Reference yield:

piperidine (110-89-4) + 4-methylphenyl 4-nitrophenyl carbonate (439688-37-6) → piperidine-1-carboxylic acid p-tolyl ester (132906-02-6) + p-nitrophenolate (14609-74-6)

Guidance literature:

With potassium chloride; In ethanol; water; at 25 ℃; pH=10.52; Further Variations:; pH-values; Kinetics;

DOI:10.1002/kin.10046

upstream raw materials:

piperidine

Carbonic acid chloromethyl ester p-tolyl ester

p-tolyl chloroformate

4-methylphenyl 4-nitrophenyl carbonate