6-Heptenoic acid, 7-[5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl]-5- hydroxy-3-oxo-, ethyl ester, (E)-

Base Information

Chemical Name:6-Heptenoic acid, 7-[5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl]-5- hydroxy-3-oxo-, ethyl ester, (E)-
CAS No.:133258-38-5
Molecular Formula:C26H28FN3O4
Molecular Weight:465.524
Hs Code.:

Synonyms:

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Chemical Property of 6-Heptenoic acid, 7-[5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl]-5- hydroxy-3-oxo-, ethyl ester, (E)-

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Technology Process of 6-Heptenoic acid, 7-[5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl]-5- hydroxy-3-oxo-, ethyl ester, (E)-

There total 10 articles about 6-Heptenoic acid, 7-[5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl]-5- hydroxy-3-oxo-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 133258-38-5
ethyl (E)-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:

Reference yield:

: 114433-94-2
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

: 133258-38-5
ethyl (E)-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) NaH, 2.) n-BuLi

With n-butyllithium; sodium hydride; trichlorophosphate; nickel; In formic acid; acetic acid;
DOI:10.1021/jm00089a022

Reference yield:

: 4930-98-7
pyrid-2-ylhydrazine

: 133258-38-5
ethyl (E)-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) NaH, 2.) n-BuLi

With n-butyllithium; sodium hydride; trichlorophosphate; nickel; In formic acid; acetic acid;
DOI:10.1021/jm00089a022