3,3-Dichloro-1-methylquinoline-2,4-dione

Base Information

• Chemical Name: 3,3-Dichloro-1-methylquinoline-2,4-dione
• CAS No.: 1968-21-4
• Molecular Formula: C10H7Cl2NO2
• Molecular Weight: 244.0741
• DSSTox Substance ID: DTXSID80382851
• Nikkaji Number: J3.149.145B
• Wikidata: Q82174317
• ChEMBL ID: CHEMBL1538966
• Mol file: 1968-21-4.mol

Synonyms:3,3-dichloro-1-methylquinoline-2,4-dione;1968-21-4;SMR000203331;MLS000584168;3,3-dichloro-1-methyl-1,2,3,4-tetrahydroquinoline-2,4-dione;CHEMBL1538966;BDBM54733;cid_2785054;DTXSID80382851;HMS2623D04;3,3-dichloro-1-methyl-quinoline-2,4-quinone;3,3-bis(chloranyl)-1-methyl-quinoline-2,4-dione;1-Methyl-3,3-dichloroquinoline-2,4(1H,3H)-dione;3,3-Dichloro-1-methylquinoline-2,4(1H,3H)-dione

Chemical Property of 3,3-Dichloro-1-methylquinoline-2,4-dione

Chemical Property:

• Vapor Pressure: 1.15E-07mmHg at 25°C
• Boiling Point: 431.9°Cat760mmHg
• Flash Point: 215°C
• Density: 1.51g/cm³
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 242.9853839
• Heavy Atom Count: 15
• Complexity: 317

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C(=O)C(C1=O)(Cl)Cl

Technology Process of 3,3-Dichloro-1-methylquinoline-2,4-dione

There total 3 articles about 3,3-Dichloro-1-methylquinoline-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

4-hydroxy-1-methyl-3-nitro-2-(1H)quinolinone (36949-55-0) → 1-Methyl-3,3-dichlor-2,4-dioxo-1,2,3,4-tetrahydrochinolin (1968-21-4)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; benzene; for 0.0833333h; Heating;

Reference yield:

4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) → 1-Methyl-3,3-dichlor-2,4-dioxo-1,2,3,4-tetrahydrochinolin (1968-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / HNO₃, H₂SO₄ / acetic acid / 48 h

2: 27 percent / SOCl₂ / benzene; dimethylformamide / 0.08 h / Heating

With thionyl chloride; sulfuric acid; nitric acid; In acetic acid; N,N-dimethyl-formamide; benzene;

Reference yield:

→ 1-Methyl-3,3-dichlor-2,4-dioxo-1,2,3,4-tetrahydrochinolin (1968-21-4)

Guidance literature:

4-Hydroxy-1-methylcarbostyril 1. Chlorid-Chlorat-Gemisch 2. wss. H2SO4, 50grad;

upstream raw materials:

4-hydroxy-1-methyl-3-nitro-2-(1H)quinolinone

4-hydroxy-1-methyl-2(1H)-quinolone