Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-methyl-, ethyl ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-methyl-, ethyl ester
• CAS No.: 133427-00-6
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.22500
• Mol file: 133427-00-6.mol

Synonyms:2-Methyl-imidazo[1,2-a]pyridine-8-carboxylic acid ethyl ester;Ethyl (2-methylimidazo[1,2-a]pyridin-8-yl)carboxylate;ethyl 2-methyl-imidazo[1,2-a]-pyridine-8-carboxylate;

Chemical Property of Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-methyl-, ethyl ester

Chemical Property:

• PSA: 43.60000
• LogP: 1.81940

Purity/Quality:

98% ^*data from raw suppliers

2-methyl-Imidazo[1,2-a]pyridine-8-carboxylicacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-methyl-, ethyl ester

There total 2 articles about Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-aminopyridine-3-carboxylic acid ethyl ester (13362-26-0) + chloroacetone (78-95-5) → ethyl 2-methylimidazo[1,2-a]pyridine-8-carboxylate (133427-00-6)

Guidance literature:

In ethanol; for 24h; Heating;

DOI:10.1021/jo800700b

Reference yield: 50.0%

→ ethyl 2-methylimidazo[1,2-a]pyridine-8-carboxylate (133427-00-6)

Guidance literature:

Reference yield: 42.0%

ethyl 2-methylimidazo[1,2-a]pyridine-8-carboxylate (133427-00-6) → 8-(hydroxymethyl)-2-methylimidazo<1,2-a>pyridine (85333-34-2)

Guidance literature:

ethyl 2-methylimidazo[1,2-a]pyridine-8-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3.5h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2010.01.023

upstream raw materials:

2-aminopyridine-3-carboxylic acid ethyl ester

chloroacetone

Downstream raw materials:

8-(hydroxymethyl)-2-methylimidazo<1,2-a>pyridine

Refernces

• 1、 -. "IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS". Page/Page column 18. . Retrieved 2010/04/30.