Butanoic acid, [(1R,2S)-2-formylcyclopropyl]methyl ester

Base Information

Chemical Name:Butanoic acid, [(1R,2S)-2-formylcyclopropyl]methyl ester
CAS No.:133494-60-7
Molecular Formula:C9H14O3
Molecular Weight:170.208
Hs Code.:

Synonyms:

Suppliers and Price of Butanoic acid, [(1R,2S)-2-formylcyclopropyl]methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Butanoic acid, [(1R,2S)-2-formylcyclopropyl]methyl ester

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanoic acid, [(1R,2S)-2-formylcyclopropyl]methyl ester

There total 1 articles about Butanoic acid, [(1R,2S)-2-formylcyclopropyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 826-34-6
dimethyl cis-cyclopropane-1,2-dicarboxylate

: 133494-60-7
(1R,2S)-1-butyroyloxymethyl-2-formylcyclopropane

Guidance literature:: Multi-step reaction with 4 steps

1: LAH / diethyl ether / 0.5 h / 0 °C

2: DMAP, TEA / CH₂Cl₂ / 1 h / Ambient temperature

3: 1M NaOH / ethane-1,2-diol; H₂O / 3 °C / lipase (PPL)

4: PCC, NaOAc, molecular sieves / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sodium hydroxide; lithium aluminium tetrahydride; molecular sieve; TEA; sodium acetate; pyridinium chlorochromate; In diethyl ether; dichloromethane; water; ethylene glycol;
DOI:10.1016/S0040-4020(01)86378-X

Reference yield:

: 133494-60-7
(1R,2S)-1-butyroyloxymethyl-2-formylcyclopropane

: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-hexyl-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuOK / tetrahydrofuran / -80 - 20 °C

1.2: 70 percent / tetrahydrofuran / -78 - 20 °C

2.1: 98 percent / K₂CO₃ / methanol / 2.75 h / 20 °C

3.1: 87 percent / hydrazine hydrate; aq. CuSO₄; aq. NaIO₄ / acetic acid; propan-2-ol

4.1: Et₃N / diethyl ether / 16 h / 20 °C

With sodium periodate; potassium tert-butylate; potassium carbonate; hydrazine hydrate; copper(II) sulfate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; acetic acid; isopropyl alcohol; 1.2: Wittig reaction;
DOI:10.1016/S0957-4166(03)00165-4

Reference yield:

: 133494-60-7
(1R,2S)-1-butyroyloxymethyl-2-formylcyclopropane

: 252009-68-0
(1R,2S)-2-hexylcyclopropane-1-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuOK / tetrahydrofuran / -80 - 20 °C

1.2: 70 percent / tetrahydrofuran / -78 - 20 °C

2.1: 98 percent / K₂CO₃ / methanol / 2.75 h / 20 °C

3.1: 87 percent / hydrazine hydrate; aq. CuSO₄; aq. NaIO₄ / acetic acid; propan-2-ol

4.1: 94 percent / PCC; NaOAC; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

With sodium periodate; 4 A molecular sieve; potassium tert-butylate; sodium acetate; potassium carbonate; hydrazine hydrate; copper(II) sulfate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; acetic acid; isopropyl alcohol; 1.2: Wittig reaction;
DOI:10.1016/S0957-4166(03)00165-4