Dihydropyrimidine-2,4,5(3H)-trione

Base Information

• Chemical Name: Dihydropyrimidine-2,4,5(3H)-trione
• CAS No.: 496-76-4
• Molecular Formula: C4H4N2O3
• Molecular Weight: 128.087
• Hs Code.: 2933599550
• European Community (EC) Number: 207-829-9
• NSC Number: 95958
• UNII: 438WJI1S49
• DSSTox Substance ID: DTXSID40964293
• Nikkaji Number: J27.896C
• Mol file: 496-76-4.mol

Synonyms:5-hydroxyuracil

Chemical Property of Dihydropyrimidine-2,4,5(3H)-trione

Chemical Property:

• Melting Point: >300 °C (dec.)(lit.)
• Refractive Index: 1.492
• Boiling Point: 534.5oC at 760mmHg
• PKA: 8.25±0.20(Predicted)
• Flash Point: 277oC
• PSA: 85.95000
• Density: 1.455g/cm³
• LogP: -1.23120
• Solubility.: Soluble in DMSO (Sparingly), Methanol (Sparingly).
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 128.02219199
• Heavy Atom Count: 9
• Complexity: 186

Purity/Quality:

98%,99%, ^*data from raw suppliers

Isobarbituric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)C(=O)NC(=O)N1
• Uses: A 5-hydroxy derivative of the nucleobase Uracil (U801000) and an isomer of Barbituric Acid (B118650). Studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been u sed as oxidative DNA damage biomarker in tissue engineered skin 2,4,5-Trihydroxypyrimidine studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. It acts as an antagonist of uracil in the growth of Lactobacillus casei.

Technology Process of Dihydropyrimidine-2,4,5(3H)-trione

There total 1 articles about Dihydropyrimidine-2,4,5(3H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ dihydropyrimidine-2,4,5(3H)-trione (496-76-4)

Guidance literature:

Uracil, H2O2, FeSO4, Ethylendiamin-tetraacetat-Na-salz, 37grad, in Phosphatlsg. bei pH 7.2;

Refernces