Combretastatin A5

Base Information

Chemical Name:Combretastatin A5
CAS No.:117048-60-9
Molecular Formula:C₁₈H₂₀O₅
Molecular Weight:316.354
Hs Code.:
NSC Number:613730
DSSTox Substance ID:DTXSID701188478
Nikkaji Number:J435.581D
ChEMBL ID:CHEMBL44704
Mol file:117048-60-9.mol

Synonyms:combretastatin A-5;combretastatin A-6;combretastatin A5;combretastatin A6;combretastatin, (E)-isomer

Suppliers and Price of Combretastatin A5

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Combretastatin A5

Chemical Property:

Vapor Pressure:2.05E-10mmHg at 25°C
Boiling Point:494.8°Cat760mmHg
Flash Point:253.1°C
PSA：57.15000
Density:1.184g/cm³
LogP:3.59700
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:316.13107373
Heavy Atom Count:23
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)O)OC
Isomeric SMILES:COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)O)OC

Technology Process of Combretastatin A5

There total 10 articles about Combretastatin A5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 121042-97-5
3'-<(tert-butyldimethylsilyl)oxy>combretastatin A-5

: 117048-60-9
combretastatin A-5

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;
DOI:10.1021/jm00010a011

Reference yield:

: 3'-<(tert-butyldimethylsilyl)oxy>combretastatin A-6

: 117048-60-9
combretastatin A-6

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;
DOI:10.1021/jm00010a011

Reference yield:

: 61240-20-8
triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide

: 117048-60-9
combretastatin A-6

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) butyllithium / 1.) THF, -23 deg C, 60 min, 2.) THF, a) -23 deg C, 4 h, b) RT, 14 h

2: tetrabutylammonium fluoride / tetrahydrofuran / 0.33 h

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jm00010a011