Chemical Property of 3-Amino-4-[(1H-indol-5-yl)methylidene]pent-2-ene-1,1,5-tricarbonitrile
Chemical Property:
- Boiling Point:714.1±60.0 °C(Predicted)
- PKA:15.95±0.30(Predicted)
- PSA：113.18000
- Density:1.396±0.06 g/cm3(Predicted)
- LogP:3.03514
- Storage Temp.:−20°C
- Solubility.:DMSO: soluble
- XLogP3:2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:4
- Exact Mass:287.11709544
- Heavy Atom Count:22
- Complexity:601
- Purity/Quality:
-
≥95% *data from raw suppliers
AG-370 ≥95% (cis/trans mixture) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC2=C(C=CN2)C=C1C=C(CC#N)C(=CC(C#N)C#N)N
-
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 μM).
