N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE

Base Information

• Chemical Name: N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE
• CAS No.: 134430-88-9
• Molecular Formula: C16H15NO
• Molecular Weight: 237.301
• Mol file: 134430-88-9.mol

Synonyms:

Chemical Property of N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE

Chemical Property:

• PSA: 29.10000
• LogP: 3.71990

Purity/Quality:

99% ^*data from raw suppliers

(E)-N-(4-methylphenyl)-3-phenylprop-2-enamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE

There total 17 articles about N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-toluidine (106-49-0,12221-03-3) + Cinnamoyl chloride (102-92-1,17082-09-6) → (2E)-N-(4-methylphenyl)-3-phenylprop-2-enamide (134430-88-9)

Guidance literature:

With potassium carbonate; In water; acetone; at 0 ℃; for 2h;

DOI:10.1002/cmdc.201300319

Reference yield: 97.0%

6-bromomethyl-1-ethyl-1,2-dihydroquinolin-2-one (133032-63-0) + p-toluidine (106-49-0,12221-03-3) → (2E)-N-(4-methylphenyl)-3-phenylprop-2-enamide (134430-88-9)

Guidance literature:

With pyridine; hydrogenchloride; In dichloromethane; water;

Reference yield: 97.0%

→ (2E)-N-(4-methylphenyl)-3-phenylprop-2-enamide (134430-88-9)

Guidance literature:

upstream raw materials:

(E)-3-phenylacrylic acid

p-toluidine

Cinnamoyl chloride

syn/anti-p-Tolyl-trans-styryl-ketoxim

Downstream raw materials:

1-(p-Tolyl)-1,2-dihydroquinolin-2-one

6-methylquinolin-2(1H)-one

(Z)-N-(4-metilfenil)-3-fenilpropenamida

N-benzoylformyl-N-(p-tolyl)cinnamamide

Refernces

• 1、 Peng, Jin-Bao,Geng, Hui-Qing,Li, Da,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng. "Palladium-Catalyzed Carbonylative Synthesis of α,β-Unsaturated Amides from Styrenes and Nitroarenes". supporting information. p. 4988 - 4993. Retrieved 2018/08/24.
• 2、 Rokade, Balaji V.,Gadde, Karthik,Prabhu, Kandikere Ramaiah. "Copper-catalyzed direct transformation of secondary allylic and benzylic alcohols into azides and amides: An efficient utility of azide as a nitrogen source". . p. 2706 - 2717. Retrieved 2015/04/27.