2-[3-(Trifluoromethyl)anilino]benzamide

Base Information

• Chemical Name: 2-[3-(Trifluoromethyl)anilino]benzamide
• CAS No.: 13481-61-3
• Molecular Formula: C14H11F3N2O
• Molecular Weight: 280.249
• DSSTox Substance ID: DTXSID50354904
• Wikidata: Q82133392
• ChEMBL ID: CHEMBL2152567
• Mol file: 13481-61-3.mol

Synonyms:2-[3-(trifluoromethyl)anilino]benzamide;13481-61-3;CHEMBL2152567;Benzamide, 2-[[3-(trifluoromethyl)phenyl]amino]-;2-{[3-(trifluoromethyl)phenyl]amino}benzamide;2-[(3-trifluoromethylphenyl)amino]-benzamide;CBDivE_012401;SCHEMBL9270625;DTXSID50354904;HMS1578L07;BDBM50392063;AKOS001063780;2-(3-(Trifluoromethyl)Phenylamino)Benzamide;AE-848/32589053;EN300-18221615;SR-01000196871;SR-01000196871-1;Z56935839

Chemical Property of 2-[3-(Trifluoromethyl)anilino]benzamide

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 280.08234746
• Heavy Atom Count: 20
• Complexity: 346

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)C(F)(F)F

Technology Process of 2-[3-(Trifluoromethyl)anilino]benzamide

There total 3 articles about 2-[3-(Trifluoromethyl)anilino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

flufenamic acid (530-78-9) → 2-<<3-(trifluoromethyl)phenyl>amino>benzamide (13481-61-3)

Guidance literature:

flufenamic acid; With thionyl chloride; In toluene; for 1h; Reflux;

With ammonium hydroxide;

DOI:10.1016/j.bmcl.2016.09.020

Reference yield:

ethyl N-(α,α,α-trifluoro-m-tolyl)-anthranilate (2766-16-7) → 2-<<3-(trifluoromethyl)phenyl>amino>benzamide (13481-61-3)

Guidance literature:

With ammonia; sodium methylate; In methanol;

DOI:10.1021/jm00307a025

Reference yield:

→ 2-<<3-(trifluoromethyl)phenyl>amino>benzamide (13481-61-3)

Guidance literature:

entspr.Ester, NH3;

upstream raw materials:

ethyl N-(α,α,α-trifluoro-m-tolyl)-anthranilate

flufenamic acid

Downstream raw materials:

2-Cyclopropyl-1-(3-trifluoromethyl-phenyl)-1H-quinazolin-4-one

1-(m-Trifluormethyl)-2-methyl-4-oxo-1,4-dihydrochinazolin

2-Isopropyl-1-(3-trifluoromethyl-phenyl)-1H-quinazolin-4-one

2-Chloromethyl-1-(3-trifluoromethyl-phenyl)-1H-quinazolin-4-one