BOC-3-(3'-QUINOLYL)-L-ALANINE

Base Information

Chemical Name:BOC-3-(3'-QUINOLYL)-L-ALANINE
CAS No.:135101-20-1
Molecular Formula:C17H20N2O4
Molecular Weight:316.35200
Hs Code.:
Mol file:135101-20-1.mol

Synonyms:β-(3-quinolyl)-N-Boc-L-alanine;(S)-2-tert-Butoxycarbonylamino-3-quinolin-3-yl-propionic acid;(2S)-2-[(TERT-BUTOXY)CARBONYLAMINO]-3-(3-QUINOLYL)PROPANOIC ACID;

Suppliers and Price of BOC-3-(3'-QUINOLYL)-L-ALANINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2S)-2-[(TERT-BUTOXY)CARBONYLAMINO]-3-(3-QUINOLYL)PROPANOIC ACID 95.00%
1G
$ 2027.55

American Custom Chemicals Corporation
(2S)-2-[(TERT-BUTOXY)CARBONYLAMINO]-3-(3-QUINOLYL)PROPANOIC ACID 95.00%
5MG
$ 504.71

Total 3 raw suppliers

Chemical Property of BOC-3-(3'-QUINOLYL)-L-ALANINE

Chemical Property:

Boiling Point:518.5±45.0 °C(Predicted)
PKA:3.43±0.10(Predicted)
PSA：88.52000
Density:1.235±0.06 g/cm3(Predicted)
LogP:3.14610

Purity/Quality:

99.90% ^*data from raw suppliers

(2S)-2-[(TERT-BUTOXY)CARBONYLAMINO]-3-(3-QUINOLYL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of BOC-3-(3'-QUINOLYL)-L-ALANINE

There total 10 articles about BOC-3-(3'-QUINOLYL)-L-ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 135213-90-0,1954-41-2
β-(3-quinolyl)-L-alanine

: 135101-20-1,1100747-96-3
(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-quinolinepropanoic acid

Guidance literature:: With sodium hydroxide; In tert-butyl alcohol;

Reference yield:

: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(quinolin-3-yl)propanoate

: 135101-20-1,1100747-96-3
(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-quinolinepropanoic acid

Guidance literature:: With (butylcarbamoyl)-L-tryptophan; In methanol; water; at 20 ℃;
DOI:10.1039/c9cc01330j

Reference yield:

: 104325-51-1
3-(chloromethyl)-quinoline

: 135101-20-1,1100747-96-3
(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-quinolinepropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF a) 90 deg C, 6 h, b) RT, overnight

2: 6 M aq. NaOH / aq. ethanol / 1.5 h / Ambient temperature

3: dioxane / 3 h / Heating

5: 6 M aq. HCl / 4 h / Heating

6: 58 percent / aq. NaOH / 2-methyl-propan-2-ol

With hydrogenchloride; sodium hydroxide; sodium hydride; In 1,4-dioxane; ethanol; tert-butyl alcohol;