2-Chloro-4-(1-piperidinylcarbonyl)quinoline

Base Information

• Chemical Name: 2-Chloro-4-(1-piperidinylcarbonyl)quinoline
• CAS No.: 135323-96-5
• Molecular Formula: C15H15ClN2O
• Molecular Weight: 274.74500
• DSSTox Substance ID: DTXSID701247351
• Nikkaji Number: J420.737H
• ChEMBL ID: CHEMBL1888683
• Mol file: 135323-96-5.mol

Synonyms:2-chloro-4-(1-piperidinylcarbonyl)quinoline;(2-chloroquinolin-4-yl)-piperidin-1-ylmethanone;135323-96-5;Oprea1_687406;MLS000568297;(2-Chloro-quinolin-4-yl)-piperidin-1-yl-methanone;CHEMBL1888683;DTXSID701247351;HMS2476N23;STL300985;AKOS000604971;2-Chloro-4-(piperidinocarbonyl)quinoline;SMR000178439;(2-Chloro-4-quinolinyl)-1-piperidinylmethanone;(2-chloroquinolin-4-yl)(piperidin-1-yl)methanone;AK-918/14108002;SR-01000322171;SR-01000322171-1

Chemical Property of 2-Chloro-4-(1-piperidinylcarbonyl)quinoline

Chemical Property:

• Boiling Point: 464.3±30.0 °C(Predicted)
• PKA: -0.44±0.50(Predicted)
• PSA: 33.20000
• Density: 1.284±0.06 g/cm3(Predicted)
• LogP: 3.45220
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 274.0872908
• Heavy Atom Count: 19
• Complexity: 330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C2=CC(=NC3=CC=CC=C32)Cl

Technology Process of 2-Chloro-4-(1-piperidinylcarbonyl)quinoline

There total 1 articles about 2-Chloro-4-(1-piperidinylcarbonyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 2-chloroquinoline-4-carbonyl chloride (2388-32-1) → (2-chloroquinolin-4-yl)(piperidin-1-yl)methanone (135323-96-5)

Guidance literature:

With benzene;

Reference yield: 91.0%

(2-chloroquinolin-4-yl)(piperidin-1-yl)methanone (135323-96-5) + ethyl 2-cyanoacetate (105-56-6) → cyano-[4-(piperidine-1-carbonyl)-quinolin-2-yl]-acetic acid ethyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 6h;

DOI:10.1007/BF02218830

Reference yield: 86.0%

(2-chloroquinolin-4-yl)(piperidin-1-yl)methanone (135323-96-5) + malononitrile (109-77-3) → 2-[4-(piperidine-1-carbonyl)-quinolin-2-yl]-malononitrile

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 3h;

DOI:10.1007/BF02218830

upstream raw materials:

piperidine

2-chloroquinoline-4-carbonyl chloride

Downstream raw materials:

Benzoic acid N'-[4-(piperidine-1-carbonyl)-quinolin-2-yl]-hydrazide

(1-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-5-yl)-piperidin-1-yl-methanone

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