5-amino-1-ethyl-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

Base Information

• Chemical Name: 5-amino-1-ethyl-3,3-dimethyl-2,3-dihydro-1H-indol-2-one
• CAS No.: 135437-78-4
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.26800
• Mol file: 135437-78-4.mol

Synonyms:5-amino-1-ethyl-3,3-dimethyl-1,3-dihydroindol-2-one;5-amino-1-ethyl-3,3-dimethylindolin-2-one;2H-Indol-2-one,5-amino-1-ethyl-1,3-dihydro-3,3-dimethyl;

Chemical Property of 5-amino-1-ethyl-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

Chemical Property:

• PSA: 46.33000
• LogP: 2.55910

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-1-ethyl-3,3-dimethyl-1,3-dihydro-indol-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-1-ethyl-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

There total 1 articles about 5-amino-1-ethyl-3,3-dimethyl-2,3-dihydro-1H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethyl-3,3-dimethyl-5-nitro-1H-indol-2-one (135437-77-3) → 5-amino-1-ethyl-3,3-dimethyl-1,3-dihydroindol-2-one (135437-78-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 18h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/jm800052b

Reference yield:

5-amino-1-ethyl-3,3-dimethyl-1,3-dihydroindol-2-one (135437-78-4) + (E)-2-(hydroxymethylene)cyclohexan-1-one (823-45-0,39695-64-2,72036-60-3) → C18H23N3O2

Guidance literature:

5-amino-1-ethyl-3,3-dimethyl-1,3-dihydroindol-2-one; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.166667h;

(E)-2-(hydroxymethylene)cyclohexan-1-one; With sodium acetate; In methanol; water; at 0 ℃; for 2h;

upstream raw materials:

1-ethyl-3,3-dimethyl-5-nitro-1H-indol-2-one