3,4-dichlorobenzyloxyacetic acid

Base Information

• Chemical Name: 3,4-dichlorobenzyloxyacetic acid
• CAS No.: 82513-28-8
• Molecular Formula: C9H8 Cl2 O3
• Molecular Weight: 235.06
• Mol file: 82513-28-8.mol

Synonyms:Aceticacid, [(3,4-dichlorophenyl)methoxy]- (9CI); 3,4-Dichlorobenzyloxyacetic acid

Chemical Property of 3,4-dichlorobenzyloxyacetic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.59460

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-dichlorobenzyloxyacetic acid

There total 1 articles about 3,4-dichlorobenzyloxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,4-dichlorobenzyl alcohol (1805-32-9) + bromoacetic acid (79-08-3) → <(3,4-dichlorobenzyl)oxy>acetic acid (82513-28-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 8h; Heating;

DOI:10.1021/jm00351a002

Reference yield:

<(3,4-dichlorobenzyl)oxy>acetic acid (82513-28-8) → (3,4-Dichloro-benzyloxy)-acetyl chloride

Guidance literature:

With thionyl chloride; at 70 ℃; for 2h;

DOI:10.1021/jm00374a006

Reference yield:

<(3,4-dichlorobenzyl)oxy>acetic acid (82513-28-8) → <(3,4-dichlorobenzyl)oxy>propionic acid (90296-11-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 2 h / 70 °C

2: diethyl ether

3: Na₂S₂O₃, Na₂CO₃, Ag₂O, water / dioxane / 3 h / 90 °C

With thionyl chloride; water; sodium carbonate; sodium thiosulfate; silver(l) oxide; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jm00374a006

upstream raw materials:

3,4-dichlorobenzyl alcohol

bromoacetic acid

Downstream raw materials:

<(3,4-dichlorobenzyl)oxy>propionic acid

Refernces

• 1、 Abraham, D. J.,Kennedy, P. E.,Mehanna, A. S.,Patwa, D. C.,Williams, F. L.. "Design, Synthesis, and Testing of Potential Antisickling Agents. 4. Structure-Activity Relationships of Benzyloxy and Phenoxy Acids". . p. 967 - 978. Retrieved 2007/10/02.