1,4-Naphthalenediol, 5,7,8-trimethoxy-2-(phenylethynyl)-

Base Information

Chemical Name:1,4-Naphthalenediol, 5,7,8-trimethoxy-2-(phenylethynyl)-
CAS No.:136009-00-2
Molecular Formula:C₂₁H₁₈O₅
Molecular Weight:350.371
Hs Code.:
Mol file:136009-00-2.mol

Synonyms:

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Chemical Property of 1,4-Naphthalenediol, 5,7,8-trimethoxy-2-(phenylethynyl)-

Chemical Property:

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Technology Process of 1,4-Naphthalenediol, 5,7,8-trimethoxy-2-(phenylethynyl)-

There total 7 articles about 1,4-Naphthalenediol, 5,7,8-trimethoxy-2-(phenylethynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135-77-3
1,2,4-trimethoxy-benzene

: 136009-00-2
5,7,8-Trimethoxy-2-phenylethynyl-naphthalene-1,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / Br₂ / CHCl₃ / 0.75 h / 0 °C

2: 82 percent / LDA / tetrahydrofuran / 4 h / -78 °C

3: 70percent aq. perchloric acid / tetrahydrofuran / 1.25 h

4: 80 percent / pyridinium bromide perbromide / tetrahydrofuran / 1 h / 0 deg C to rt

5: 69 percent / Na₂Cr₂O₇, aq. H₂SO₄ / acetone / 3 h / 0 - 4 °C

6: 77 percent / CuI, i-Pr₂NEt / (Ph₃P)4Pd / dimethylformamide / 18 h

7: aq. Na₂S₂O₄, Bu₄NBr / CH₂Cl₂

With copper(l) iodide; perchloric acid; sodium dithionite; sodium dichromate; sulfuric acid; tetrabutylammomium bromide; bromine; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: 20129-11-7
1-bromo-2,4,5-trimethoxybenzene

: 136009-00-2
5,7,8-Trimethoxy-2-phenylethynyl-naphthalene-1,4-diol

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / LDA / tetrahydrofuran / 4 h / -78 °C

2: 70percent aq. perchloric acid / tetrahydrofuran / 1.25 h

3: 80 percent / pyridinium bromide perbromide / tetrahydrofuran / 1 h / 0 deg C to rt

4: 69 percent / Na₂Cr₂O₇, aq. H₂SO₄ / acetone / 3 h / 0 - 4 °C

5: 77 percent / CuI, i-Pr₂NEt / (Ph₃P)4Pd / dimethylformamide / 18 h

6: aq. Na₂S₂O₄, Bu₄NBr / CH₂Cl₂

With copper(l) iodide; perchloric acid; sodium dithionite; sodium dichromate; sulfuric acid; tetrabutylammomium bromide; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 135678-82-9
5,7,8-trimethoxynaphthalen-1-ol

: 136009-00-2
5,7,8-Trimethoxy-2-phenylethynyl-naphthalene-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridinium bromide perbromide / tetrahydrofuran / 1 h / 0 deg C to rt

2: 69 percent / Na₂Cr₂O₇, aq. H₂SO₄ / acetone / 3 h / 0 - 4 °C

3: 77 percent / CuI, i-Pr₂NEt / (Ph₃P)4Pd / dimethylformamide / 18 h

4: aq. Na₂S₂O₄, Bu₄NBr / CH₂Cl₂

With copper(l) iodide; sodium dithionite; sodium dichromate; sulfuric acid; tetrabutylammomium bromide; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;