Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester

Base Information

Chemical Name:Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester
CAS No.:13605-37-3
Molecular Formula:C13H16O5
Molecular Weight:252.267
Hs Code.:
DSSTox Substance ID:DTXSID70443167
Mol file:13605-37-3.mol

Synonyms:13605-37-3;Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester;DTXSID70443167

Suppliers and Price of Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:252.09977361
Heavy Atom Count:18
Complexity:319

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(O1)C2=CC(=C(C=C2)OC)OC)C(=O)OC

Technology Process of Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester

There total 1 articles about Oxiranecarboxylic acid, 3-(3,4-dimethoxyphenyl)-2-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17639-93-9
2-chloro-propionic acid methyl ester

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 13605-37-3
3-(3,4-dimethoxy-phenyl)-2,3-epoxy-2-methyl-propionic acid methyl ester

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 46h; Yield given;

Reference yield:

: 13605-37-3
3-(3,4-dimethoxy-phenyl)-2,3-epoxy-2-methyl-propionic acid methyl ester

: 776-99-8
3,4-dimethoxyphenylacetone

Guidance literature:: 3-(3,4-dimethoxy-phenyl)-2,3-epoxy-2-methyl-propionic acid methyl ester; With sodium hydroxide; In toluene; for 1h;

With hydrogenchloride; In toluene; at 60 - 95 ℃; for 5h; pH=2.5; Further stages.;
DOI:10.1055/s-2008-1067002

Reference yield:

: 13605-37-3
3-(3,4-dimethoxy-phenyl)-2,3-epoxy-2-methyl-propionic acid methyl ester

: (2S^*,3S^*,4R^*)-4-(3,4-dimethoxyphenyl)-3-methyl-2-(3-oxobutyl)-2-(2-propenyl)-4-butanonolide

Guidance literature:: Multi-step reaction with 11 steps

1: NaOH / methanol / 0.5 h / Heating

2: 89.2 percent / pyridine / benzene / 5 h / Heating

3: 76.9 percent / TiCl₄, pyridine / CH₂Cl₂ / 4 h / Ambient temperature

4: conc. HCl / methanol / 1 h / Heating

5: NaBH₄ / methanol / 0.33 h

6: 82.6 percent / Et₃N / tetrahydrofuran

7: 20percent aq. NaOH / methanol / 1 h / Heating

8: HCl / methanol / 0.67 h / Ambient temperature

9: 98.5 percent / CH(OCH₃)3, BF*Et₂O / ethanol / 1.5 h / 0 - 5 °C

10: 1.) LDA / 1.) THF, hexane, -60 deg C, 15 min, 2.) THF, hexane, a) -30 deg C, 30 min, b) from 0 to 5 deg C, 2 h

11: 96.5 percent / 10percent metanolic HCl / 3 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; BF*Et₂O; titanium tetrachloride; triethylamine; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1248/cpb.43.2099