Imidazo[1,2-a]pyridine-8-carbonitrile

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-8-carbonitrile
• CAS No.: 136117-70-9
• Molecular Formula: C8H5N3
• Molecular Weight: 143.14500
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID301287577
• Mol file: 136117-70-9.mol

Synonyms:imidazo[1,2-a]pyridine-8-carbonitrile;136117-70-9;MFCD09994637;SCHEMBL325037;MYTKOOVOBCDRPN-UHFFFAOYSA-N;DTXSID301287577;AKOS006313552;AS-8158;PB23788;SY143094;CS-0055258;EN300-113178;P10889;F8889-7353;Z1198268332

Chemical Property of Imidazo[1,2-a]pyridine-8-carbonitrile

Chemical Property:

• PKA: 2.56±0.50(Predicted)
• PSA: 41.09000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 1.20598
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 143.048347172
• Heavy Atom Count: 11
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

imidazo[1,2-a]pyridine-8-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=CN=C2C(=C1)C#N

Technology Process of Imidazo[1,2-a]pyridine-8-carbonitrile

There total 2 articles about Imidazo[1,2-a]pyridine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloroethanal (107-20-0) + 2-amino-3-pyridinecarbonitrile (24517-64-4) → 8-imidazo<1,2-a>pyridinecarbonitrile (136117-70-9)

Guidance literature:

In ethanol; at 120 ℃; Sealed tube;

Reference yield: 72.0%

2-amino-3-pyridinecarbonitrile (24517-64-4) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 8-imidazo<1,2-a>pyridinecarbonitrile (136117-70-9)

Guidance literature:

In butan-1-ol; Heating;

DOI:10.1248/cpb.39.1556

Reference yield: 100.0%

8-imidazo<1,2-a>pyridinecarbonitrile (136117-70-9) → imidazo[1,2-a]pyridin-8-ylmethanamine (933721-91-6)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 20 ℃;

upstream raw materials:

2-amino-3-pyridinecarbonitrile

Bromoacetaldehyde diethyl acetal

2-chloroethanal

Downstream raw materials:

methyl 8-imidazo<1,2-a>pyridinecarboxylate

8-imidazo<1,2-a>pyridinecarboxaldehyde

imidazo[1,2-a]pyridin-8-ylmethanamine

3-iodoimidazo[1,2-a]pyridine-8-carbonitrile