Chemical Property of Procyanidin B1
Chemical Property:
- Appearance/Colour:Red-Brown Powder
- Melting Point:231～232℃
- Boiling Point:955.3 °C at 760 mmHg
- PKA:9.29±0.60(Predicted)
- Flash Point:531.6 °C
- PSA：220.76000
- Density:1.705g/cm3
- LogP:2.99500
- Storage Temp.:2-8°C
- Solubility.:Acetone (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
- XLogP3:2.4
- Hydrogen Bond Donor Count:10
- Hydrogen Bond Acceptor Count:12
- Rotatable Bond Count:3
- Exact Mass:578.14242626
- Heavy Atom Count:42
- Complexity:925
- Purity/Quality:
-
≥98% *data from raw suppliers
Procyanidin B1 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
- Isomeric SMILES:C1[C@@H]([C@H](OC2=C1C(=CC(=C2[C@@H]3[C@H]([C@H](OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
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Description
Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin and (?)-epicatechin . It inhibits hepatitis C virus RNA replication (EC50 = 72 μM), while (+)-catechin and (?)-epicatechin do not, up to concentrations of 200 μM. Procyanidin B1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells. It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.
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Uses
Procyanidins B1 is a B type proanthocyanidins found in ceylon cinnamon and is known to exhibit anti-inflammatory effects.
