2-amino-6-trifluoromethylbenzonorbornene

Base Information

• Chemical Name: 2-amino-6-trifluoromethylbenzonorbornene
• CAS No.: 83118-50-7
• Molecular Formula: C₁₂H₁₂F₃N
• Molecular Weight: 227.229
• Mol file: 83118-50-7.mol

Synonyms:2-amino-6-trifluoromethylbenzonorbornene

Chemical Property of 2-amino-6-trifluoromethylbenzonorbornene

Chemical Property:

• Vapor Pressure: 0.0116mmHg at 25°C
• Boiling Point: 261.4°C at 760 mmHg
• Flash Point: 114°C
• PSA: 26.02000
• Density: 1.29g/cm³
• LogP: 3.70760

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-6-trifluoromethylbenzonorbornene

There total 4 articles about 2-amino-6-trifluoromethylbenzonorbornene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-((1S,2R,4S)-6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-yl)-isoindole-1,3-dione (86022-66-4) → (1S,2R,4S)-6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-ylamine (83118-50-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1021/jo00162a005

Reference yield:

exo-6-(Trifluoromethyl)benzonorbornen-2-ol (50781-99-2) → (1S,2R,4S)-6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-ylamine (83118-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P, diethyl azidodicarboxylate / tetrahydrofuran / 36 h / Ambient temperature

2: 81 percent / 85percent NH₂NH₂*H₂O / ethanol / 3 h / Heating

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00162a005

Reference yield:

6-(Trifluoromethyl)benzonorbornen-2-one (69103-41-9) → (1S,2R,4S)-6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-ylamine (83118-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent Turnov_. / diborane / tetrahydrofuran / 3.5 h / Ambient temperature

2: 64 percent / Ph₃P, diethyl azidodicarboxylate / tetrahydrofuran / 56 h / Ambient temperature

3: 81 percent / 85percent NH₂NH₂*H₂O / ethanol / 3 h / Heating

With hydrazine hydrate; triphenylphosphine; diborane; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00162a005

upstream raw materials:

2-((1S,2R,4S)-6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-yl)-isoindole-1,3-dione

6-(Trifluoromethyl)benzonorbornen-2-one

exo-6-(Trifluoromethyl)benzonorbornen-2-ol

endo-6-(Trifluoromethyl)benzonorbornen-2-ol

Refernces