Technology Process of Benzenepropanoic acid, 3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]-
There total 7 articles about Benzenepropanoic acid, 3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
1.) RT, 10 min, 2.) reflux, 1 h;
DOI:10.1021/jm00097a006
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Na, 2.) H2SO4 / 1.) EtOH, 15 min, 2.) EtOH, reflux, 2.25 h
2: NH4OAc / acetic acid / 1 h / Heating
3: 90 percent / pyridine / 0 °C
4: 88 percent / Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / 24 h / 90 °C
5: 90 percent / H2 / 10percent Pd/C / ethyl acetate / 27 h / 1810.02 Torr
6: 91 percent / 5N aq. NaOH / methanol / 1.) RT, 10 min, 2.) reflux, 1 h
With
palladium diacetate; sodium hydroxide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; ammonium acetate; hydrogen; sodium; triethylamine;
palladium on activated charcoal;
In
pyridine; methanol; acetic acid; ethyl acetate;
DOI:10.1021/jm00097a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / 10percent Pd/C / methanol / 4 h / 2327.2 - 2585.7 Torr
2: 1.) Na, 2.) H2SO4 / 1.) EtOH, 15 min, 2.) EtOH, reflux, 2.25 h
3: NH4OAc / acetic acid / 1 h / Heating
4: 90 percent / pyridine / 0 °C
5: 88 percent / Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / 24 h / 90 °C
6: 90 percent / H2 / 10percent Pd/C / ethyl acetate / 27 h / 1810.02 Torr
7: 91 percent / 5N aq. NaOH / methanol / 1.) RT, 10 min, 2.) reflux, 1 h
With
palladium diacetate; sodium hydroxide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; ammonium acetate; hydrogen; sodium; triethylamine;
palladium on activated charcoal;
In
pyridine; methanol; acetic acid; ethyl acetate;
DOI:10.1021/jm00097a006
