Methanone,[(3S,4R,5R)-5-(3,4-dimethoxyphenyl) tetrahydro-4-(hydroxymethyl)-3- furanyl](3,4,5-trimethoxyphenyl)-

Base Information

Chemical Name:Methanone,[(3S,4R,5R)-5-(3,4-dimethoxyphenyl) tetrahydro-4-(hydroxymethyl)-3- furanyl](3,4,5-trimethoxyphenyl)-
CAS No.:95263-43-7
Molecular Formula:C₂₃H₂₈O₈
Molecular Weight:432.471
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanone,[(3S,4R,5R)-5-(3,4-dimethoxyphenyl) tetrahydro-4-(hydroxymethyl)-3- furanyl](3,4,5-trimethoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methanone,[(3S,4R,5R)-5-(3,4-dimethoxyphenyl) tetrahydro-4-(hydroxymethyl)-3- furanyl](3,4,5-trimethoxyphenyl)-

There total 3 articles about Methanone,[(3S,4R,5R)-5-(3,4-dimethoxyphenyl) tetrahydro-4-(hydroxymethyl)-3- furanyl](3,4,5-trimethoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (+)-(2R,3R,4S)-2-(3,4-dimethoxyphenyl)-4-{(2-(3,4,5-trimethoxyphenyl)-1,3-dithian-2-yl)tetrahydrofuran-3-yl}-methanol

: 95263-43-7
(+)-sylvone

Guidance literature:: With mercury dichloride; mercury(II) oxide; In water; acetonitrile; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.joc.5b01677

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 95263-43-7
(+)-sylvone

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 °C / Inert atmosphere

4.1: mercury(II) oxide; mercury dichloride / acetonitrile; water / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetonitrile; 2.1: |Michael Addition / 2.2: |Michael Addition;
DOI:10.1021/acs.joc.5b01677

Reference yield:

: (-)-(S)-methyl-2-{(3,4-dimethoxyphenyl)(hydroxy)methyl}-buta-2,3-dienoate

: 95263-43-7
(+)-sylvone

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver nitrate / acetone / 12 h / 40 °C / Darkness; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 °C / Inert atmosphere

4.1: mercury(II) oxide; mercury dichloride / acetonitrile; water / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; silver nitrate; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; hexane; water; acetone; acetonitrile; 2.1: |Michael Addition / 2.2: |Michael Addition;
DOI:10.1021/acs.joc.5b01677