(2r,2'r)-2,2'-Bipyrrolidine

Base Information

• Chemical Name: (2r,2'r)-2,2'-Bipyrrolidine
• CAS No.: 137037-20-8
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• European Community (EC) Number: 630-773-5
• Nikkaji Number: J1.456.701A
• Mol file: 137037-20-8.mol

Synonyms:(2r,2'r)-2,2'-bipyrrolidine;137037-20-8;(2R)-2-[(2R)-Pyrrolidin-2-yl]pyrrolidine;SCHEMBL16563030;107886-22-6;MFCD12911900;AKOS006349338;(2R,2'R)-(-)-2,2'-Bipyrrolidine;CS-0097200;(2r,2'r)-(-)-2,2'-Bipyrrolidine,99%;D75871

Chemical Property of (2r,2'r)-2,2'-Bipyrrolidine

Chemical Property:

• Melting Point: 212-216 °C(Solv: water (7732-18-5))
• Boiling Point: 150 °C(Press: 15 Torr)
• PKA: 10.72±0.10(Predicted)
• PSA: 24.06000
• Density: 0.979±0.06 g/cm3(Predicted)
• LogP: 1.14800
• Storage Temp.: 2-8°C
• Sensitive.: air sensitive
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 140.131348519
• Heavy Atom Count: 10
• Complexity: 99.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R,2'R)-(-)-2,2'-Bipyrrolidine, 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 5376257
• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C2CCCN2
• Isomeric SMILES: C1C[C@@H](NC1)[C@H]2CCCN2

Technology Process of (2r,2'r)-2,2'-Bipyrrolidine

There total 16 articles about (2r,2'r)-2,2'-Bipyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(±)-1,1'-([2,2'-bipyrrolidine]-1,1'-diyl)bis(2,2,2-trifluoroethan-1-one) → 2,2'-bipyrrolidine (74295-58-2,107886-07-7,107886-22-6,124779-66-4,137037-20-8)

Guidance literature:

With potassium hydroxide; In methanol; at 23 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01768

Reference yield: 84.0%

(2R,2’R)-2,2’-bipyrrolidine L-tartrate → (R,R)-2,2'-bipyrrolidine (137037-20-8)

Guidance literature:

With sodium hydroxide; In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1021/ja016552e

Reference yield: 83.0%

dl-1,1'-dibenzoyl-2,2'-bipyrrolidine (136937-01-4,136937-02-5) → 2,2'-bipyrrolidine (74295-58-2,107886-07-7,107886-22-6,124779-66-4,137037-20-8)

Guidance literature:

With hydrogenchloride; for 48h; Heating;

DOI:10.1055/s-1991-26576

upstream raw materials:

dl-1,1'-dibenzoyl-2,2'-bipyrrolidine

N,N'-Bis[(S)-1-phenylethyl]-(R,R)-2,2'-bipyrrolidine

2,2’-bipyrrolidine

2-(3,4-dihydro-2H-pyrrol-5-yl)pyrrole

Downstream raw materials:

C₄₆H₄₂N₂O₂P₂

(2R,2′R)-1,1′-bis({[2-(diphenylphosphanyl)phenyl]methyl})-2,2′-bipyrrolidine

C₃₆H₄₀N₂O₂

C₂₂H₂₄Br₄N₂O₂

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