N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester

Base Information

Chemical Name:N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester
CAS No.:137255-89-1
Molecular Formula:C25H27NO4
Molecular Weight:405.494
Hs Code.:
DSSTox Substance ID:DTXSID701133730
Nikkaji Number:J443.878G

Synonyms:SCHEMBL1823733;DTXSID701133730;N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester;N-[(1,1-Dimethylethoxy)carbonyl]-4-(1-naphthalenyl)-L-phenylalanine methyl ester;137255-89-1

Suppliers and Price of N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:405.19400834
Heavy Atom Count:30
Complexity:576

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=C(C=C1)C2=CC=CC3=CC=CC=C32)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CC=C(C=C1)C2=CC=CC3=CC=CC=C32)C(=O)OC

Technology Process of N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester

There total 2 articles about N-(tert-Butoxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 90-14-2
1-Iodonaphthalene

: methyl N-tert-butyloxycarbonyl-L-(4-trimethylstannylphenyl)alaninate

: 137255-89-1
N-(t-butyloxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; In N,N-dimethyl-formamide; at 60 ℃; for 2.5h;
DOI:10.1055/s-0030-1260179

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 137255-89-1
N-(t-butyloxycarbonyl)-4-(1-naphthyl)-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 1) K₂CO₃ / 2) Pd(PPh₃)4 / 1) toluene, 15 min, 2) 3 h, 85-90 deg C

With pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;
DOI:10.1021/jo00027a066