Carbamic acid, [1-[[4-(1,1-dimethylethoxy)-2,6-dimethylphenyl]methyl]-2-oxo-4-[[(3-phen ylpropyl)amino]carbonyl]-4-pentenyl]-, 1,1-dimethylethyl ester, (S)-

Base Information

Chemical Name:Carbamic acid, [1-[[4-(1,1-dimethylethoxy)-2,6-dimethylphenyl]methyl]-2-oxo-4-[[(3-phen ylpropyl)amino]carbonyl]-4-pentenyl]-, 1,1-dimethylethyl ester, (S)-
CAS No.:137650-22-7
Molecular Formula:C33H46N2O5
Molecular Weight:550.739
Hs Code.:

Carbamic acid,
[1-[[4-(1,1-dimethylethoxy)-2,6-dimethylphenyl]methyl]-2-oxo-4-[[(3-phen
ylpropyl)amino]carbonyl]-4-pentenyl]-, 1,1-dimethylethyl ester, (S)-

Synonyms:

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Chemical Property of Carbamic acid, [1-[[4-(1,1-dimethylethoxy)-2,6-dimethylphenyl]methyl]-2-oxo-4-[[(3-phen ylpropyl)amino]carbonyl]-4-pentenyl]-, 1,1-dimethylethyl ester, (S)-

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Technology Process of Carbamic acid, [1-[[4-(1,1-dimethylethoxy)-2,6-dimethylphenyl]methyl]-2-oxo-4-[[(3-phen ylpropyl)amino]carbonyl]-4-pentenyl]-, 1,1-dimethylethyl ester, (S)-

There total 7 articles about Carbamic acid, [1-[[4-(1,1-dimethylethoxy)-2,6-dimethylphenyl]methyl]-2-oxo-4-[[(3-phen ylpropyl)amino]carbonyl]-4-pentenyl]-, 1,1-dimethylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2038-57-5
3-Phenylpropan-1-amine

: 137650-22-7
1,1-dimethyl <2-1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-4-methylene-2,5-dioxo-5-<(3-phenylpropyl)amino>pentyl>carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 2.5 h

With n-butyllithium; triethylamine; In dichloromethane;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-17-0
1,1-dimethylethyl <2-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-1(S)-formylethyl>carbamate

: 137650-22-7
1,1-dimethyl <2-1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-4-methylene-2,5-dioxo-5-<(3-phenylpropyl)amino>pentyl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 0.5N aq. LiOH / tetrahydrofuran / 0.25 h

2: 4-methylmorpholine / tetrahydrofuran / 0.75 h / -23 °C

3: 4-methylmorpholine / tetrahydrofuran / 1 h

4: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 2.5 h

With 4-methyl-morpholine; lithium hydroxide; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-15-8
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)propanoate

: 137650-22-7
1,1-dimethyl <2-1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-4-methylene-2,5-dioxo-5-<(3-phenylpropyl)amino>pentyl>carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / BF₃*Et₂O / CH₂Cl₂ / 16 h / 0 °C

2: Dibal-H / toluene / -78 °C

3: 99 percent / 0.5N aq. LiOH / tetrahydrofuran / 0.25 h

4: 4-methylmorpholine / tetrahydrofuran / 0.75 h / -23 °C

5: 4-methylmorpholine / tetrahydrofuran / 1 h

6: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 2.5 h

With 4-methyl-morpholine; lithium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00080a005