6-Hydroxydopa

Base Information

Chemical Name:6-Hydroxydopa
CAS No.:21373-30-8
Molecular Formula:C₉H₁₁NO₅
Molecular Weight:213.19
Hs Code.:
UNII:9HBL9XYQ8O
DSSTox Substance ID:DTXSID00943928
Nikkaji Number:J640.425A
Wikidata:Q27109347
Pharos Ligand ID:FLY456W5GLC2
ChEMBL ID:CHEMBL109037
Mol file:21373-30-8.mol

Synonyms:2,4,5-trihydroxyphenyl-D,L-alanine;2,4,5-trihydroxyphenylalanine;2,5-dihydroxytyrosine;3,4,6-TOPA;3,4,6-trihydroxyphenylalanine;6-hydroxydopa;6-hydroxydopa, (D)-isomer;6-hydroxydopa, (DL)-isomer;6-hydroxydopa, (L)-isomer;6-hydroxydopa, hydrochloride;6-hydroxydopa, hydrochloride, (L)-isomer;6-OHDOPA

Suppliers and Price of 6-Hydroxydopa

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Hydroxy-DL-DOPA
2.5mg
$ 280.00

Sigma-Aldrich
6-Hydroxy-DL-DOPA ≥98% (TLC), powder
100mg
$ 3130.00

Sigma-Aldrich
6-Hydroxy-DL-DOPA ≥98% (TLC), powder
5mg
$ 234.00

Sigma-Aldrich
6-Hydroxy-DL-DOPA ≥98% (TLC), powder
10mg
$ 448.00

American Custom Chemicals Corporation
6-HYDROXY-DL-DOPA 95.00%
100MG
$ 3189.53

American Custom Chemicals Corporation
6-HYDROXY-DL-DOPA 95.00%
10MG
$ 907.75

American Custom Chemicals Corporation
6-HYDROXY-DL-DOPA 95.00%
5MG
$ 776.91

American Custom Chemicals Corporation
6-HYDROXY-DL-DOPA 95.00%
2MG
$ 483.00

Total 11 raw suppliers

Chemical Property of 6-Hydroxydopa

Chemical Property:

Boiling Point:515.2°Cat760mmHg
PKA:2.34±0.25(Predicted)
Flash Point:265.4°C
PSA：124.01000
Density:1.606g/cm³
LogP:0.45810
Storage Temp.:−20°C
Solubility.:H2O: soluble3mg/mL (Dissolve in oxygen-free boiled water contain
XLogP3:-2.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:213.06372245
Heavy Atom Count:15
Complexity:235

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Hydroxy-DL-DOPA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1O)O)O)CC(C(=O)O)N
Uses 6-Hydroxy-DL-DOPA is a catecholamine neurotoxin and endogenous exicitotoxin even at non-NMDA receptors.

Technology Process of 6-Hydroxydopa

There total 10 articles about 6-Hydroxydopa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31222-25-0
2.4.5-Tribenzyloxy-DL-phenylalanin

: 23358-64-7,21373-30-8
3-(2,4,5-trihydroxyphenyl)-DL-alanine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00285a034

Reference yield:

: 30223-59-7
5-<2,4,5-tris(benzyloxy)benzyl>hydantoin

: 23358-64-7,21373-30-8
3-(2,4,5-trihydroxyphenyl)-DL-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. KOH / 2-methoxy-ethanol

2: H₂ / Pd-C / methanol

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; 2-methoxy-ethanol;
DOI:10.1021/jm00285a034

Reference yield:

: 22892-32-6
2.4.5-Tribenzyloxy-benzylalkohol

: 23358-64-7,21373-30-8
3-(2,4,5-trihydroxyphenyl)-DL-alanine

Guidance literature:: Multi-step reaction with 3 steps

1: PBr₃ / CCl₄

2: NaH

3: (i) H₂, Pd-C, EtOH, aq. HCl, (ii) (heating)

With phosphorus tribromide; sodium hydride; In tetrachloromethane;
DOI:10.1021/jm00303a028