trans-(4-(4-Chlorophenyl)cyclohexyl)methyl bromide

Base Information

• Chemical Name: trans-(4-(4-Chlorophenyl)cyclohexyl)methyl bromide
• CAS No.: 137736-29-9
• Molecular Formula: C13H16BrCl
• Molecular Weight: 287.627
• DSSTox Substance ID: DTXSID401209411
• Mol file: 137736-29-9.mol

Synonyms:trans-(4-(4-chlorophenyl)cyclohexyl)methyl bromide;SCHEMBL9264845;SCHEMBL9264848;WEPDWWFTSVHBMQ-XYPYZODXSA-N;DTXSID401209411;137736-29-9;Benzene, 1-[trans-4-(bromomethyl)cyclohexyl]-4-chloro-

Chemical Property of trans-(4-(4-Chlorophenyl)cyclohexyl)methyl bromide

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 286.01239
• Heavy Atom Count: 15
• Complexity: 179

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(CCC1CBr)C2=CC=C(C=C2)Cl

Technology Process of trans-(4-(4-Chlorophenyl)cyclohexyl)methyl bromide

There total 1 articles about trans-(4-(4-Chlorophenyl)cyclohexyl)methyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

[trans-4-(4-chlorophenyl)cyclohexyl]methanol (137736-28-8) → 1-[trans-4-(bromomethyl)cyclohexyl]-4-chlorobenzene (137736-29-9)

Guidance literature:

With sulfuric acid; hydrogen bromide; at 140 ℃; for 5.5h;

DOI:10.1021/jm0705760

Reference yield: 54.0%

1-[trans-4-(bromomethyl)cyclohexyl]-4-chlorobenzene (137736-29-9) + acetic anhydride (108-24-7) → 1-[trans-4-(4-chlorophenyl)cyclohexyl]propan-2-one (137736-27-7)

Guidance literature:

1-[trans-4-(bromomethyl)cyclohexyl]-4-chlorobenzene; With iodine; magnesium; In diethyl ether; for 0.5h; Heating;

acetic anhydride; In diethyl ether; at -78 - 0 ℃; Further stages.;

DOI:10.1021/jm0705760

upstream raw materials:

[trans-4-(4-chlorophenyl)cyclohexyl]methanol

Downstream raw materials:

1-[trans-4-(4-chlorophenyl)cyclohexyl]propan-2-one

Refernces