(5-Chloro-6-methylpyridin-2-yl)methanol

Base Information

• Chemical Name: (5-Chloro-6-methylpyridin-2-yl)methanol
• CAS No.: 137778-09-7
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.59800
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50568125
• Wikidata: Q82454290
• Mol file: 137778-09-7.mol

Synonyms:(5-Chloro-6-methylpyridin-2-yl)methanol;137778-09-7;DTXSID50568125;SB54581

Chemical Property of (5-Chloro-6-methylpyridin-2-yl)methanol

Chemical Property:

• Boiling Point: 238.8±35.0 °C(Predicted)
• PKA: 12.96±0.10(Predicted)
• PSA: 33.12000
• Density: 1.263±0.06 g/cm3(Predicted)
• LogP: 1.53570
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 157.0294416
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

95% ^*data from raw suppliers

(5-Chloro-6-methylpyridin-2-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)CO)Cl

Technology Process of (5-Chloro-6-methylpyridin-2-yl)methanol

There total 3 articles about (5-Chloro-6-methylpyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2,6-dimethylpyridine (2405-06-3) → 3-chloro-2-methyl-6-pyridylmethanol (137778-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 h / 120 °C

2: 1) Ac₂O, 2) 3percent HCl / 1) 120 deg C, 3 h, 2) 60 deg C, 4 h then 24 h, RT

With hydrogenchloride; acetic anhydride;

DOI:10.1016/S0022-2860(96)09359-3

Reference yield:

Acetic acid 5-chloro-2,6-dimethyl-pyridin-3-yl ester (137778-13-3) → 3-chloro-2-methyl-6-pyridylmethanol (137778-09-7) + 3-chloro-2,6-dimethyl-5-hydroxypyridine (137778-10-0)

Guidance literature:

With hydrogenchloride; acetic anhydride; Yield given. Multistep reaction; 1) 120 deg C, 3 h, 2) 60 deg C, 4 h then 24 h, RT;

DOI:10.1016/S0022-2860(96)09359-3

Reference yield:

3-chloro-2,6-dimethylpyridine N-oxide (3512-76-3) + acetic anhydride (108-24-7) → 3-chloro-2-methyl-6-pyridylmethanol (137778-09-7) + 3-chloro-2,6-dimethyl-5-hydroxypyridine (137778-10-0)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) 120 deg C, 3 h, 2.) a.) 60 deg C, 4 h, b.) RT, 24 h;

upstream raw materials:

3-chloro-2,6-dimethylpyridine N-oxide

acetic anhydride

Acetic acid 5-chloro-2,6-dimethyl-pyridin-3-yl ester

3-chloro-2,6-dimethylpyridine

Downstream raw materials:

3-chloro-6-formyl-2-methylpyridine

3-chloro-2-methylpyridine