Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Base Information

Chemical Name:Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
CAS No.:5909-24-0
Molecular Formula:C8H9ClN2O2S
Molecular Weight:232.691
Hs Code.:29339900
European Community (EC) Number:227-619-0
NSC Number:123534
UNII:3EZY6B6CLY
DSSTox Substance ID:DTXSID20207832
Nikkaji Number:J124.092G
Wikidata:Q72473705
Mol file:5909-24-0.mol

Synonyms:4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester;ethyl 4-chloro-MPC

Suppliers and Price of Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ethyl 4-Chloro-2-methylthiopyrimidine-5-carboxylate
5g
$ 326.00

TRC
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate
50 g
$ 275.00

TRC
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate
5 g
$ 60.00

TRC
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate
1g
$ 45.00

TCI Chemical
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate >97.0%(GC)
5g
$ 47.00

TCI Chemical
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate >97.0%(GC)
25g
$ 141.00

Sigma-Aldrich
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%
25g
$ 170.00

Sigma-Aldrich
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%
5g
$ 54.50

Sigma-Aldrich
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%
100g
$ 682.00

Medical Isotopes, Inc.
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate
5 g
$ 1680.00

Total 171 raw suppliers

Chemical Property of Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Chemical Property:

Appearance/Colour:off white to light yellow solid
Vapor Pressure:0mmHg at 25°C
Melting Point:60-63 °C(lit.)
Refractive Index:1.568
Boiling Point:335.7 °C at 760 mmHg
PKA:-2.19±0.29(Predicted)
Flash Point:156.83 °C
PSA：77.38000
Density:1.37 g/cm³
LogP:2.02860
Storage Temp.:Keep Cold
Solubility.:Chloroform, Ethyl Acetate
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:232.0073264
Heavy Atom Count:14
Complexity:206

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 4-Chloro-2-methylthiopyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C(N=C1Cl)SC
Uses A pyrimidine derivative as inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus cerevisiae Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate was used in the synthesis of pyrimidinopyridones, potential inhibitors of the FMS tyrosine kinase.

Technology Process of Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

There total 5 articles about Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With thionyl chloride; at 60 ℃; for 3h;

Reference yield: 84.5%

: sodium 5-(ethoxycarbonyl)-2-(methylthio)-4-oxo-4H-pyrimidin-3-ide

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: sodium 5-(ethoxycarbonyl)-2-(methylthio)-4-oxo-4H-pyrimidin-3-ide; With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 20 - 30 ℃; for 0.5h; Large scale;

With trichlorophosphate; In N,N-dimethyl-formamide; toluene; at 55 - 65 ℃; for 1.5h; Large scale;