Technology Process of L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-a-aspartyl-,
bis(phenylmethyl) ester
There total 7 articles about L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-a-aspartyl-,
bis(phenylmethyl) ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
BOC-L-aspartic acid 4-benzyl ester;
With
1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
L-phenylalanine benzyl ester hydrochloride;
With
4-methyl-morpholine;
In
tetrahydrofuran;
at 20 ℃;
for 8h;
pH=8.5;
Further stages.;
DOI:10.1021/jm070242a
- Guidance literature:
-
BOC-L-aspartic acid 4-benzyl ester;
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
(S)-phenylalanine benzyl ester benzene sulfonate;
With
4-methyl-morpholine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1039/c5md00215j
- Guidance literature:
-
BOC-L-aspartic acid 4-benzyl ester;
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
L-phenylalanine benzyl ester p-toluene-sulfonic acid salt;
With
triethylamine;
In
tetrahydrofuran;
at 20 ℃;
