4-(Chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole

Base Information

• Chemical Name: 4-(Chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole
• CAS No.: 138128-84-4
• Molecular Formula: C10H7ClFNS
• Molecular Weight: 227.69
• European Community (EC) Number: 869-811-2
• Mol file: 138128-84-4.mol

Synonyms:4-(chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole;138128-84-4;AKOS000138567;EN300-68238;G20799

Chemical Property of 4-(Chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 226.9971763
• Heavy Atom Count: 14
• Complexity: 193

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=NC(=CS2)CCl)F

Technology Process of 4-(Chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole

There total 1 articles about 4-(Chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluorobenzonitrile (394-47-8) → 4-(chloromethyl)-2-(2-fluorophenyl)thiazole (138128-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; triethylamine; diammonium sulfide / water / 50 °C

2: toluene / Reflux

With pyridine; diammonium sulfide; triethylamine; In water; toluene;

DOI:10.1021/jm401643m

Reference yield: 50.0%

4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-mercaptopyrimidine-5-carbonitrile (1589080-67-0) + 4-(chloromethyl)-2-(2-fluorophenyl)thiazole (138128-84-4) → 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(2-fluorophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile (1589081-25-3)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1021/jm401643m

Reference yield: 22.0%

4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-mercaptopyrimidine-5-carbonitrile (1589080-67-0) + 4-(chloromethyl)-2-(2-fluorophenyl)thiazole (138128-84-4) → 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-trifluoromethylphenyl)-thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile (1589081-26-4)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1021/jm401643m

upstream raw materials:

2-fluorobenzonitrile

Downstream raw materials:

{3-[2-(2-Fluoro-phenyl)-thiazol-4-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(2-fluorophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile

4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-trifluoromethylphenyl)-thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 138128-84-4 Thiazole, 4-(chloromethyl)-2-(2-fluorophenyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send