1-(2-Hydroxyphenyl)-2-methoxyethan-1-one

Base Information

• Chemical Name: 1-(2-Hydroxyphenyl)-2-methoxyethan-1-one
• CAS No.: 138206-45-8
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• DSSTox Substance ID: DTXSID30569478
• Wikidata: Q82456637
• Mol file: 138206-45-8.mol

Synonyms:138206-45-8;1-(2-hydroxyphenyl)-2-methoxyethanone;1-(2-Hydroxyphenyl)-2-methoxyethan-1-one;SCHEMBL11542107;DTXSID30569478

Chemical Property of 1-(2-Hydroxyphenyl)-2-methoxyethan-1-one

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 156

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=O)C1=CC=CC=C1O

Technology Process of 1-(2-Hydroxyphenyl)-2-methoxyethan-1-one

There total 4 articles about 1-(2-Hydroxyphenyl)-2-methoxyethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2'-Benzyloxy-2-methoxyacetophenone (138206-44-7) → 2'-Hydroxy-2-methoxyacetophenone (138206-45-8)

Guidance literature:

With hydrogen; palladium; In ethanol; for 1h;

DOI:10.1248/cpb.39.2301

Reference yield:

(2-(benzyloxy)phenyl)magnesium bromide (328000-16-4) → 2'-Hydroxy-2-methoxyacetophenone (138206-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) 1 N aq. HCl / 1.) THF, 2 h, room temperature, 2.) 30 min, reflux

2: 96 percent / H₂ / Pd-black / ethanol / 1 h

With hydrogenchloride; hydrogen; palladium; In ethanol;

DOI:10.1248/cpb.39.2301

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + O-acetylsalicyloyl chloride (5538-51-2) → 2'-Hydroxy-2-methoxyacetophenone (138206-45-8)

Guidance literature:

With diethyl ether; und Erwaermen des Reaktionsprodukts mit Methanol und Kupfer-Pulver und Erwaermen des danach erhaltenen Reaktionsprodukts mit wss.Alkali;

upstream raw materials:

diazomethane

O-acetylsalicyloyl chloride

2'-Benzyloxy-2-methoxyacetophenone

3-methoxyflavone

Downstream raw materials:

3,4'-Dimethoxyflavone

α,2'-dimethoxy-chalcone

1-[(E)-1-(2-Hexyloxy-phenyl)-2-methoxy-vinyl]-1H-imidazole

1-[(E)-2-Methoxy-1-(2-pentyloxy-phenyl)-vinyl]-1H-imidazole