tert-butyl N-(2-oxo-4-phenylbutyl)carbamate

Base Information

Chemical Name:tert-butyl N-(2-oxo-4-phenylbutyl)carbamate
CAS No.:138371-68-3
Molecular Formula:C₁₅H₂₁NO₃
Molecular Weight:263.337
Hs Code.:
DSSTox Substance ID:DTXSID001179567

Synonyms:138371-68-3;tert-butyl N-(2-oxo-4-phenylbutyl)carbamate;DTXSID001179567;EN300-12458059;Carbamic acid, (2-oxo-4-phenylbutyl)-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl N-(2-oxo-4-phenylbutyl)carbamate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:263.15214353
Heavy Atom Count:19
Complexity:301

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC(=O)CCC1=CC=CC=C1

Technology Process of tert-butyl N-(2-oxo-4-phenylbutyl)carbamate

There total 1 articles about tert-butyl N-(2-oxo-4-phenylbutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 31419-53-1
1-amino-4-phenyl-2-butan-one hydrochloride

: 138371-68-3
1-N-tert-butoxycarbonylamino-4-phenyl-2-butanone

Guidance literature:: With dmap; triethylamine; In acetonitrile; for 0.5h; Ambient temperature;
DOI:10.1139/v91-298

Reference yield:

: 138371-68-3
1-N-tert-butoxycarbonylamino-4-phenyl-2-butanone

: 138371-66-1
3-Phenyl-1-pyrrolidin-2-yl-propan-1-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, NaH, 0 deg C, 0.25 h, 2) DMF, 0 deg C, 1 h

2: 74 percent / conc. HCl / methanol / 1 h / Heating

With hydrogenchloride; sodium hydride; In methanol;
DOI:10.1139/v91-298

Reference yield:

: 138371-68-3
1-N-tert-butoxycarbonylamino-4-phenyl-2-butanone

: 138371-67-2
3-Phenyl-1-piperidin-2-yl-propan-1-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, NaH, 0 deg C, 0.25 h, 2) DMF, 0 deg C, 1 h

2: 71 percent / conc. HCl / methanol / 1 h / Heating

With hydrogenchloride; sodium hydride; In methanol;
DOI:10.1139/v91-298